801220-52-0Relevant academic research and scientific papers
Recognition of double-stranded dna using energetically activated duplexes modified with N2′-pyrene-, perylene-, or coronene-functionalized 2′- N -methyl-2′-amino-DNA monomers
Anderson, Brooke A.,Onley, Jared J.,Hrdlicka, Patrick J.
, p. 5395 - 5406 (2015/06/16)
Invader probes have been proposed as alternatives to polyamides, triplex-forming oligonucleotides, and peptide nucleic acids for recognition of chromosomal DNA targets. These double-stranded probes are activated for DNA recognition by +1 interstrand zippe
High-affinity DNA targeting using readily accessible mimics of N2′-functionalized 2′-amino-α-L-LNA
Karmakar, Saswata,Anderson, Brooke A.,Rathje, Rie L.,Andersen, Sanne,Jensen, Troels B.,Nielsen, Poul,Hrdlicka, Patrick J.
experimental part, p. 7119 - 7131 (2011/10/31)
N2′-Pyrene-functionalized 2′-amino-α-L-LNAs (locked nucleic acids) display extraordinary affinity toward complementary DNA targets due to favorable preorganization of the pyrene moieties for hybridization- induced intercalation. Unfortunately, the synthes
Conformationally controlled high-affinity targeting of RNA or DNA by novel 2′-amino-DNA/LNA mixmers and pyrenyl-functionalized 2′-amino-DNA
Kalra, Neerja,Babu, B. Ravindra,Parmar, Virinder S.,Wengel, Jesper
, p. 2885 - 2887 (2007/10/03)
9-Mer DNA sequences containing 2′-N-methyl-2′-N-(pyren-1- ylmethyl)-2′-amino-DNA monomers display significantly increased affinity towards DNA complements whereas the corresponding 2′-amino-DNA monomer has a detrimental effect on duplex stability. These e
