801228-28-4

Basic information

• Product Name: PIPERAZINE-1-CARBOXYLIC ACID (2-CHLORO-PHENYL)-AMIDE
• Synonyms: TIMTEC-BB SBB011793;PIPERAZINE-1-CARBOXYLIC ACID (2-CHLORO-PHENYL)-AMIDE
• CAS NO: 801228-28-4
• Molecular Formula: C₁₁H₁₄ClN₃O
• Molecular Weight: 239.7
• Mol File: 801228-28-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PIPERAZINE-1-CARBOXYLIC ACID (2-CHLORO-PHENYL)-AMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PIPERAZINE-1-CARBOXYLIC ACID (2-CHLORO-PHENYL)-AMIDE(801228-28-4)
• EPA Substance Registry System: PIPERAZINE-1-CARBOXYLIC ACID (2-CHLORO-PHENYL)-AMIDE(801228-28-4)

Safety Data

• Hazardous Substances Data: 801228-28-4(Hazardous Substances Data)

Upstream product

• 1315592-09-6 C₁₆H₂₂ClN₃O₃ 
• 3320-83-0 o-chlorophenyl isocyanate 

Downstream Products

• 1381950-00-0 C₂₂H₃₃ClN₄O₃ 
• 1381949-84-3 C₂₀H₂₉ClN₄O 

Relevant articles and documents

The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity

A novel N-aryl piperazine-1-carboxamide series of human CCR2 chemokine receptor antagonists was discovered. Early analogues were potent at CCR2 but also inhibited the hERG cardiac ion channel. Structural modifications which decreased lipophilicity and basicity resulted in the identification of a sub-series with an improved margin over hERG. The pharmacological and pharmacokinetic properties of the lead compound from this series, N-(3,4-dichlorophenyl)-4-[(2R)-4-isopropylpiperazine-2-carbonyl] piperazine-1-carboxamide, are described.