801250-91-9Relevant academic research and scientific papers
Photoredox-Induced Intramolecular 1,5-H Transfer Reaction of Aryl Iodides for the Synthesis of Spirocyclic γ-Lactams
Chen, Jian-Qiang,Chang, Rui,Lin, Jun-Bing,Luo, Yong-Chun,Xu, Peng-Fei
supporting information, p. 2395 - 2398 (2018/04/30)
This work develops a photocatalysis method for the synthesis of γ-spirolactams through a tandem intramolecular 1,5-HAT reaction-cyclization process. A variety of novel γ-spirolactams are prepared in good to excellent yields with this method. This transfor
Intramolecular 1,5-H transfer reaction of aryl iodides through visible-light photoredox catalysis: A concise method for the synthesis of natural product scaffolds
Chen, Jian-Qiang,Wei, Yun-Long,Xu, Guo-Qiang,Liang, Yong-Min,Xu, Peng-Fei
supporting information, p. 6455 - 6458 (2016/05/24)
The intramolecular 1,5-H transfer reaction of the aryl radicals generated from unactivated aryl iodides by photocatalysis is described. The features of this transformation are operational simplicity, excellent yields, mild reaction conditions, and good fu
Pd-catalyzed assembly of spirooxindole natural products: A short synthesis of horsfiline
Deppermann, Nina,Thomanek, Heike,Prenzel, Alexander H. G. P.,Maison, Wolfgang
experimental part, p. 5994 - 6000 (2010/12/19)
The Pd-catalyzed intramolecular α-arylation of amides is applied to the synthesis of functionalized spirooxindoles. The substrate scope is evaluated, and the reaction is demonstrated to be useful for the assembly of spirooxindole natural products and derivatives thereof. As an application, a new synthesis of horsfiline 1 is presented, giving the natural product in only 4 steps from commercially available amino acid 12.
