801281-89-0

Basic information

• Product Name: methyl 4-hydroxy-7-methoxy-8-methylquinoline-2-carboxylate
• Synonyms: methyl 4-hydroxy-7-methoxy-8-methylquinoline-2-carboxylate
• CAS NO: 801281-89-0
• Molecular Formula: C13H13NO4
• Molecular Weight: 247.24662
• Mol File: 801281-89-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: methyl 4-hydroxy-7-methoxy-8-methylquinoline-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-hydroxy-7-methoxy-8-methylquinoline-2-carboxylate(801281-89-0)
• EPA Substance Registry System: methyl 4-hydroxy-7-methoxy-8-methylquinoline-2-carboxylate(801281-89-0)

Safety Data

• Hazardous Substances Data: 801281-89-0(Hazardous Substances Data)

Upstream product

• 19500-02-8 2-methyl-3-methoxyaniline 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 801281-88-9 dimethyl 2-(3-methoxy-2-methylphenylamino)-2-butenedioate 

Downstream Products

• 923289-21-8 8-methyl-2-[4-(1-methylethyl)-1,3-thiazol-2-yl]-7-(methyloxy)-4-quinolinol 

Relevant articles and documents

Synthesis of 2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-ol; A quinoline building block for simeprevir synthesis

Two synthetic approaches to the achiral quinoline fragment of simeprevir are described. Both approaches are based on the synthesis of methyl 4-hydroxy-7-methoxy-8-methylquinoline-2-carboxylate, protection of its 4-hydroxyl group, and construction of the thiazole ring from the ester group at the 2-position. The last step is acid deprotection of the 4-hydroxyl protecting group. Georg Thieme Verlag Stuttgart. New York.

HEPATITIS C INHIBITOR COMPOUNDS

Compounds of formula (I): wherein B, X, R3, L0, L1, L2, R2, R1 and RC are defined herein. The compounds are useful as inhibitors of HCV NS3 protease for the treatment of hepatitis C viral infection.