801303-22-0

Basic information

• Product Name: 2-Amino-3-cyano-5-fluoropyridine
• Synonyms: 2-Amino-3-cyano-5-fluoropyridine;2-amino-5-fluoropyridine-3-carbonitrile
• CAS NO: 801303-22-0
• Molecular Formula: C6H4FN3
• Molecular Weight: 137.1144632
• Mol File: 801303-22-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-Amino-3-cyano-5-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-cyano-5-fluoropyridine(801303-22-0)
• EPA Substance Registry System: 2-Amino-3-cyano-5-fluoropyridine(801303-22-0)

Safety Data

• Hazardous Substances Data: 801303-22-0(Hazardous Substances Data)

Usage

General Description

2-Amino-3-cyano-5-fluoropyridine is a chemical compound with the molecular formula C6H4N3F. It is a heterocyclic building block used in the synthesis of pharmaceutical compounds and agrochemicals. 2-Amino-3-cyano-5-fluoropyridine is a potent inhibitor of the enzyme c-Jun N-terminal kinase and has potential applications in cancer therapy due to its ability to induce apoptosis and inhibit cell proliferation. Additionally, it has been studied for its potential use in the treatment of neurodegenerative diseases. 2-Amino-3-cyano-5-fluoropyridine has also been identified as a key intermediate in the synthesis of various pharmaceutical drugs and is an important building block in organic chemistry.

Upstream product

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Relevant articles and documents

An expedient Pd/DBU mediated cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6]

A practical Pd(PPh3)4/DBU catalytic system for the synthesis of pharmaceutically relevant aminopyridine nitrile intermediates, as well as a variety of other aryl nitriles using non-toxic K4[Fe(CN) 6] has been developed. The key features of our new protocol for cyanation lie in that the reaction can be carried out with readily available Pd(PPh3)4 under mild and green conditions, even without the assistance of other ligands. The Royal Society of Chemistry 2012.

Process for catalytically preparing aromatic or heteroaromatic nitriles

The present invention relates to a process for preparing optionally substituted aromatic or heteroaromatic nitriles starting from haloaromatics. These are reacted in a copper-catalysed reaction with potassium hexacyanoferrate(II) or potassium hexacyanoferrate(III) in the presence of heteroaromatic amines.

A state-of-the-art cyanation of aryl bromides: A novel and versatile copper catalyst system inspired by nature

A general protocol for the cyanation of aryl halides with the nontoxic cyanide source K4[Fe(CN)6] using copper catalysis and a ligand system based on 1-alkylimidazoles is presented. The advantages of this system are the high selectivity, a unique substrate range, easy handling, and inexpensive reagents.