801303-32-2Relevant academic research and scientific papers
5-(3-isopropyl benzisoxazol)pyrazin-2-amine and preparation method thereof
-
, (2016/12/22)
The invention discloses 5-(3-isopropyl benzisoxazol)pyrazin-2-amine and a preparation method thereof. The 5-(3-isopropyl benzisoxazol)pyrazin-2-amine has the structural formula represented by the formula (I). The compound is a new benzisoxazole compound, provides a new bactericidal drug for people, and further broadens research fields of benzoisoxazole compounds. Moreover, the reaction total yield for preparation of the compound is high, and the process is simple and is suitable for industrialized production.
RING-FUSED COMPOUND
-
Paragraph 0816-0817; 0854-0855, (2014/01/07)
The present invention relates to a compound that has URAT1 inhibitory action, and a URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition comprising the compound. More specifically, the present invention relates to a compound represented by Formula (I) below. [in the formula, R1 is -Q1-A1 and the like; ---- is a double bond or a single bond; when ---- is a double bond, W1 is a nitrogen atom or a group represented by the general formula: =C(Ra)-, and W2 is a nitrogen atom or a group represented by the general formula: =C(Rb) -; when ---- is a single bond, W1 is a group represented by the general formula: -C(Raa)(Rab)- or a group represented by the general formula: -(C=O) -, and W2 is a group represented by the general formula: C(Rba)(Rbb)-, a group represented by the general formula: - (C=O) - or a group represented by the general formula: -N(Rbc)-; W3, W4 and W5 are each independently a nitrogen atom or a methine group and the like that may have a substituent; X is a single bond, an oxygen atom and the like; Y is a single bond or (CRYiRYi')n; and Z is a hydroxyl group or COOR2 and the like.
NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES
-
Page/Page column 111, (2012/11/14)
The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.
NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES
-
Page/Page column 105, (2012/12/13)
The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.
3,5-ARYL, HETEROARYL OR CYCLOALKYL SUBSTITUTED-1,2,4-OXADIAZOLES AS S1P RECEPTOR AGONISTS
-
Page/Page column 25-26, (2008/06/13)
The present invention encompasses compounds of Formula I: (I) as well as the pharmaceutically acceptable salts thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejecti
