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Usage

Uses

Used in Cosmetic Industry:
Emulsifyingwax is used as an emulsifying agent for creating stable oil-in-water or water-in-oil emulsions in cosmetic products. It helps to bind ingredients together, providing a smooth texture and improving the stability of the formulation.
Used in Pharmaceutical Industry:
Emulsifyingwax is used as a stabilizer and emulsifier in the production of pharmaceutical creams, ointments, and lotions. It aids in the dispersion of active ingredients, ensuring even distribution and enhancing the efficacy of the product.
Used in Food Industry:
Emulsifyingwax is used as a thickening agent, emulsifier, and stabilizer in the food industry. It helps to maintain the consistency and texture of various food products, such as sauces, dressings, and baked goods, by preventing separation of ingredients.

Production Methods

Anionic emulsifying wax is prepared by melting cetostearyl alcohol and heating to about 95℃. Sodium lauryl sulfate, or some other suitable anionic surfactant, and purified water are then added. The mixture is heated to 115℃ and, while this temperature is maintained, the mixture is stirred vigorously until any frothing ceases. The wax is then rapidly cooled.

Pharmaceutical Applications

Anionic emulsifying wax is used in cosmetics and topical pharmaceutical formulations primarily as an emulsifying agent. The wax is added to fatty or paraffin bases to facilitate the production of oil-in-water emulsions that are nongreasy. In concentrations of about 2%, emulsions are pourable; stiffer emulsions, e.g. aqueous cream BP, may contain up to 10% of anionic emulsifying wax. Creams should be adequately preserved and can usually be sterilized by autoclaving. A better-quality emulsion is produced by incorporating some alkali into the aqueous phase, although care should be taken not to use an excess. Anionic emulsifying wax (3–30%) may also be mixed with soft and liquid paraffins to prepare anhydrous ointment bases such as emulsifying ointment BP. A preparation of 80% anionic emulsifying wax in white soft paraffin has been used as a soap substitute in the treatment of eczema. In addition, anionic emulsifying wax (10%) has been added to theobroma oil (cocoa butter) to produce a suppository base with a melting point of 34℃.

Safety

Anionic emulsifying wax is used primarily in topical pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material. However, sodium lauryl sulfate, a constituent of anionic emulsifying wax, is known to be irritant to the skin at high concentrations; sodium cetyl sulfate is claimed to be less irritating. Emulsifying ointment BP, which contains anionic emulsifying wax, has been found to have major sunscreen activity in clinically normal skin and should therefore not be used before phototherapy procedures.

storage

Solid anionic emulsifying wax is chemically stable and should be stored in a well-closed container in a cool, dry place.

Incompatibilities

Incompatibilities of anionic emulsifying wax are essentially those of sodium alkyl sulfates and include cationic compounds ( quaternary ammonium compounds, acriflavine, ephedrine hydrochloride, antihistamines, and other nitrogenous compounds), salts of polyvalent metals (aluminum, zinc, tin, and lead), and thioglycolates. Anionic emulsifying wax is compatible with most acids above pH 2.5. It is also compatible with alkalis and hard water. Iron vessels should not be used when heating anionic emulsifying wax; stainless steel containers are satisfactory.

Regulatory Status

Included in the FDA Inactive Ingredients Database (rectal emulsions and aerosol foams; topical aerosols, emulsions, creams, lotions, and ointments). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.