80165-40-8Relevant academic research and scientific papers
Efficient 1,4-Asymetric Induction Utilizing Electrostatic Interaction between Ligand and Substrate in the Asymmetric Hydrogenation of Didehydrodipeptides
Yamagishi, Takamichi,Ikeda, Satoru,Yatagai, Masanobu,Yamaguchi, Motowo,Hida, Mitsuhiko
, p. 1787 - 1790 (2007/10/02)
Electrostatic interaction between the amino group of the achiral 3-dimethylaminopropylidenebismethylenebis(diphenylphosphine) (1) and the carboxy group of the substrate enable an effective 1,4-asymmetric induction in the RhI-catalysed hydrogenation of didehydrodipeptides, to give (S,S)-or (R,R)-products selectively.The selectivity reached up to 94percent diastereoisomeric excess with acetyl didehydrodipeptides and 92percent with benzyloxycarbonyl substrates.
ASYMMETRIC HYDROGENATION OF DEHYDRODIPEPTIDES WITH RHODIUM(I)-CHIRAL DIPHOSPHINITES. SELECTIVE (S,S)- AND (R,R)-PRODUCT FORMATION BY DOUBLE ASYMMETRIC INDUCTION.
Yatagai,Yamagishi,Hida
, p. 823 - 826 (2007/10/02)
In the hydrogenation of dehydrodipeptides, the effect of chiral center of the substrate ((S) or (R)) on the asymmetric induction was examined using the catalysts of Rh(I)-chiral diphosphinite containing pyrrolidine moiety (POP). The catalysts with POP's h
EFFECTIVE ASYMMETRIC HYDROGENATION OF DEHYDRODIPEPTIDES WITH RHODIUM(I)-NEW CHIRAL DIPHOSPHINITE SYSTEMS
Yatagai, Masanobu,Zama, Masanobu,Yamagishi, Takamichi,Hida, Mitsuhiko
, p. 1203 - 1206 (2007/10/02)
Rh(I)-new chiral diphosphinite systems with terminal amino groups were very effective for asymmetric hydrogenation of dehydrodipeptides with free carboxyl group and a chiral carbon.The effectiveness of the diphosphinite catalysts strongly suggests the contribution of electrostatic effect to asymmetric induction.
THE ASYMMETRIC HYDROGENATION OF THE α-N-ACETYLAMINOCINNAMOYL DERIVATIVE OF AMINO ACIDS WITH CHIRAL BISPHOSPHINE-RHODIUM COMPLEX
Onuma, Ken-ichi,Ito, Tomiyasu,Nakamura, Asao
, p. 481 - 482 (2007/10/02)
An optical yield of the dipeptide obtained in the title reaction is affected by a chiral amino acid moiety in the substrate.
