80172-02-7

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 99-06-9 3-Carboxyphenol 
• 68423-35-8 ethyl (3-formylphenyl) carbonate 

Downstream Products

• 245555-64-0 3-ethoxycarbonyloxybenzoyl chloride 

Relevant academic research and scientific papers

Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: Insights into the molecular basis of kynureninase substrate specificity

Homo sapiens kynureninase is a pyridoxal-5'-phosphate dependent enzyme that catalyzes the hydrolytic cleavage of 3-hydroxykynurenine to yield 3-hydroxyanthranilate and L-alanine as part of the tryptophan catabolic pathway leading to the de novo biosynthesis of NAD+. This pathway results in quinolinate, an excitotoxin that is an NMDA receptor agonist. High levels of quinolinate have been correlated with the etiology of neurodegenerative disorders such as AIDS-related dementia and Alzheimer's disease. We have synthesized a novel kynureninase inhibitor, 3-hydroxyhippurate, cocrystallized it with human kynureninase, and solved the atomic structure. On the basis of an analysis of the complex, we designed a series of His- 102, Ser-332, and Asn-333 mutants. The H102W/N333T and H102W/S332G/N333T mutants showed complete reversal of substrate specificity between 3-hydroxykynurenine and L-kynurenine, thus defining the primary residues contributing to substrate specificity in kynureninases.

Preparation of fluorine-containing diphenyl ethers

A method of preparing a diphenyl ether compound of the formula (II) STR1 wherein X is F, Cl or Br; Z is hydrogen, halogen, NO2 of CN; and W is methyl, cyano, CH3 CO--, or a group --C--OR, wherein R is --OH; --OM wherein M is a cation; OR1 wherein R1 is an optionally substituted aliphatic radical; --NR2 R3 wherein R2 and R3 are each hydrogen or an optionally substituted aliphatic radical; or --NHSO2 R4 wherein R4 is alkyl of 1 to 6 carbon atoms, which comprises reacting a 3-X-substituted-4,5-difluorobenzotrifluoride with a salt of a 3,4-W,Z-substituted phenol. The invention further comprises novel 3-X-4,5-difluorobenzotrifluorides for use in the process.