80186-85-2Relevant academic research and scientific papers
Electrochemical oxidation of guanosine-5'-monophosphane at the pyrolytic graphite electrode
Gohal, Rajendra N.,Puri, Bal K.,Jain, Neena
, p. 832 - 837 (2007/10/03)
The electrochemical oxidation of guanosine-5'-monophosphate has been investigated in phosphate containing supporting electrolytes at pH 2.5-10.8 at a pyropytic graphite electrode by cyclic sweep voltammetry, spectral studies, controlled potential electrolysis and related techniques. The initial course of the electrode reaction has been deduced to involve a pH dependent 4e, 4H+ oxidation to give a diimine species which undergoes a series of chemical reactions to give different products. The kinetics of the decay of the UV-absorbing intermediate generated during electrooxidation has been studied at different pH values and first-order rate constants for the disappearance of the UV-absorbing intermediate have been calculated. The electrooxidation of guanosine-5'-monophosphate has been found to be an EC reaction (electrode reaction followed by chemical reactions) in which charge transfer is followed by competitive chemical reactions. The ultimate products of oxidation, urea riboside phosphate, alloxan (pyrimidine-2,4,5,6-(1H,3H)-tetraone) and a dimer were characterized by IR. 1H NMR and mass spectrometry at pH 3.4. A detailed interpretation of the redox mechanism for the formation of these products is presented.
