80194-40-7

Basic information

• Product Name: 1-(4-acetamido-2-methoxyphenoxy)-3-(p-toluenesulfonyloxy)-n-propane
• Synonyms: 1-(4-acetamido-2-methoxyphenoxy)-3-(p-toluenesulfonyloxy)-n-propane
• CAS NO: 80194-40-7
• Molecular Weight: 393.461
• Mol File: 80194-40-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-acetamido-2-methoxyphenoxy)-3-(p-toluenesulfonyloxy)-n-propane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-acetamido-2-methoxyphenoxy)-3-(p-toluenesulfonyloxy)-n-propane(80194-40-7)
• EPA Substance Registry System: 1-(4-acetamido-2-methoxyphenoxy)-3-(p-toluenesulfonyloxy)-n-propane(80194-40-7)

Safety Data

• Hazardous Substances Data: 80194-40-7(Hazardous Substances Data)

Upstream product

• 80194-39-4 1-(4-acetamido-2-methoxyphenoxy)-3-hydroxy-n-propane 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 80428-34-8 1-[3-(4-acetamido-2-methoxyphenoxy)-n-propyl]-4-phenyl-piperazine 

Relevant articles and documents

N-Aryl-N-phenoxy-alkyl-piperazine compounds useful in decreasing intracranial pressure

A piperazine derivative of the formula: STR1 wherein R1 is hydrogen, alkyl (C1-8), alkyl (C1-4)-sulfonyl or an acyl group of the formula: R3 CO--(wherein R3 is hydrogen, alkyl (C1-7), halogenoalkyl (C1-4), alkoxy (C1-4)-carbonyl-alkyl (C1-4), cycloalkyl (C3-6), alkenyl (C2-5), alkoxy (C1-4), amino, alkyl (C1-4)-amino or anilino), R2 is hydrogen, alkyl (C1-4), alkoxy (C1-4)-carbonyl-alkyl (C1-4), carboxy-alkyl (C1-4), alkenyl (C2-5) or alkyl (C1-4)-sulfonyl, or R1 and R2 are combined together to form succinyl group, Ring A is phenyl, alkyl (C1-4)-phenyl or halogenophenyl, and n is an integer of 2 to 6, or a pharmaceutically acceptable acid addition salt thereof. The piperazine derivative (I) has an intracranial pressure-lowering activity. Said derivative also has a depressing effect on central nervous system.