80195-36-4 Usage
Uses
Used in Pharmaceutical Industry:
Cefdaloxime is used as an orally administered antibiotic for the treatment of various bacterial infections. Its broad-spectrum activity makes it suitable for treating a wide range of infections caused by both Gram-negative and some Gram-positive bacteria. The primary application of Cefdaloxime is in the treatment of respiratory tract infections, urinary tract infections, and skin and soft tissue infections.
Used in Meningitis Treatment:
Cefdaloxime is used as an antimicrobial agent for the treatment of meningitis caused by Haemophilus influenzae. Its effectiveness in combating this specific bacterium makes it a valuable drug in the management of this potentially life-threatening condition.
Used as an Active Metabolite:
Cefdaloxime is also the active metabolite of HR916K, a cephalosporin ester. This means that when HR916K is administered, it is metabolized into Cefdaloxime, which then exerts its antimicrobial effects. This relationship highlights the importance of Cefdaloxime in the pharmaceutical industry as both a standalone drug and a key metabolite of other cephalosporin compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 80195-36-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,1,9 and 5 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 80195-36:
(7*8)+(6*0)+(5*1)+(4*9)+(3*5)+(2*3)+(1*6)=124
124 % 10 = 4
So 80195-36-4 is a valid CAS Registry Number.
InChI:InChI=1/C14H15N5O6S2/c1-25-2-5-3-26-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24)6-4-27-14(15)16-6/h4,8,12,24H,2-3H2,1H3,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/s1
80195-36-4Relevant academic research and scientific papers
Synthesis of HR 916 B: The first technically feasible route to the 1-(pivaloyloxy)ethyl esters of cephalosporins
Fleischmann, Klaus,Adam, Friedhelm,Duerckheimer, Walter,Hertzsch, Winfried,Hoerlein, Rolf,Jendralla, Heiner,Lefebvre, Christian,Mackiewicz, Philippe,Roul, Jean-Michel,Wollmann, Theo
, p. 1735 - 1741 (2007/10/03)
An efficient synthesis of HR 916 B (4), the orally active 1-(RS)-(pivaloyloxy)ethyl prodrug ester of the cephalosporin cefdaloxime, was developed and applied on a multi-kg scale. AMCA (8) was prepared by exchange of the acetoxy group of fermentation product ACA (7) with the nucleophile methanol under acidic conditions. Its 7-amino group was acylated with mixed anhydride 14 to give 15. Carboxylic acid 15 was esterified with iodohydrin ester 27 or bromohydrin ester 30, respectively, to provide the acylal 16. Simultaneous removal of both the amino- and the oximo-protecting group furnished the prodrug HR 916 3, which was purified and stabilized by precipitation of its tosylate salt 4. The overall yield of 4 (ratio 5/6 = 0.65) was 39% relative to AMCA (8) (four steps), 15% relative to ACA (7) (five steps). VCH Verlagsgesellschaft mbH, 1996.
