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Usage

Uses

Used in Pharmaceutical Industry:
3-(3-Nitro-phenyl)-propionitrile is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a versatile building block in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(3-Nitro-phenyl)-propionitrile serves as an intermediate for the production of various agrochemicals. Its role in this industry is crucial for the synthesis of compounds that help protect crops and enhance agricultural productivity.
Used in Dye and Pigment Production:
3-(3-Nitro-phenyl)-propionitrile is also utilized in the manufacturing of dyes and pigments. Its chemical properties make it suitable for creating a wide range of colors used in different industries, including textiles, plastics, and printing inks.

Upstream product

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• 13331-27-6 m-nitrobenzene boronic acid 
• 107-13-1 acrylonitrile 
• 645-59-0 dihydrocinnamonitrile 

Relevant academic research and scientific papers

(PYRIDIN-2-YL)AMINE DERIVATIVES AS TGF-BETA R1 (ALK5) INHIBITORS FOR THE TREATMENT OF CANCER

The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder associated with ΤGFβR1 activity, such as a cancer or fibrosis. The invention provides compounds of Formula (I) and Formula (II) as further described herein having an acidic moiety that enhances tissue specificity for targeted tissues and organs. The invention includes pharmaceutical compositions, pharmaceutical combinations, and methods of use of these compounds for treating conditions including cancer or fibrosis.

Catalyzation of 1,4-additions of arylboronic acids to α,β- unsaturated substrates using nickel(I) complexes

Nickel(I) complexes were generated in situ from Ni (PPh3) 2Cl2 using activated iron and the complexes combined with N,N′-bis(4-fluorobenzylidene) ethane-1,2-diamine (BFBED) were then used as a catalyst for the 1,4-addition reaction of arylboronic acids to α,β-unsaturated substrates. The reaction proceeded to completion and did not require the addition of a base but the addition of potassium iodide is crucial to this cross-coupling reaction. Moreover, experimental observations suggested a possible Ni(I)-Ni(III) catalytic cycle mechanism.

Diphenylurea compounds

wherein: R1, R2, R3 and R4 independently represent hydrogen, halogen, or alkyl, alkoxy, hydroxy, cyano, optionally substituted amino, nitro, carboxy, alkoxycarbonyl, optionally substituted aminocarbonyl or carba

Experiments on the Chaperon effect in the nitration of aromatics

A nitro group may be effectively delivered to the ortho position of alkylbenzenes, provided that a suitable chaperon function is located in α- position and a dilute of HNO3 in CH2Cl2 is used. The carbonyl function of an aldehyde or ketone is the best choice, but a carboxyl, alkoxycarbonyl, and amide groups all work well. The ether function showed a less pronounced ortho orientation effect, whereas the hydroxyl group was too prone to oxidation. Side reactions were minimal under the conditions employed. A para chaperon effect was seemingly at work in the CH2Cl2 nitration of benzenepropanenitrile. All the results were compared with the corresponding classical nitration in H2SO4.