802052-63-7

Usage

Derivative of pyrrole and carboxylic acid

1H-Pyrrole-2-carboxylic acid, 3-phenyl- is derived from two main structures, pyrrole (a five-membered aromatic ring with one nitrogen atom) and carboxylic acid (a carboxyl functional group -COOH).

Phenyl group attachment

A phenyl group (a benzene ring) is attached to the 3-position of the pyrrole ring, which influences the compound's chemical properties and reactivity.

Versatile reactivity

1H-Pyrrole-2-carboxylic acid, 3-phenylcan undergo various chemical reactions, making it useful in the synthesis of pharmaceuticals and agrochemicals.

Potential pharmacological activity

The compound has been studied for its anti-inflammatory and antimicrobial properties, indicating its potential as a therapeutic agent.

Value as an intermediate in drug development

Due to its pharmacological properties, 1H-Pyrrole-2-carboxylic acid, 3-phenylis a valuable intermediate in the development of new drugs.

Applications in materials science and organic chemistry

The compound has potential applications in these fields, further highlighting its versatility and value in various industries.

Upstream product

• 1323141-43-0 C₂₃H₂₂BrNO₅ 
• 1323141-42-9 C₂₃H₂₃NO₅ 
• 1323141-25-8 C₂₃H₂₄BrNO₆ 
• 1323141-24-7 C₂₃H₂₅NO₆ 
• 21390-88-5 ethyl 3-phenyl-1H-pyrrole-2-carboxylate 

Downstream Products

• 1323140-95-9 C₂₃H₂₂N₂O₂ 
• 1323140-96-0 C₂₃H₂₁BrN₂O₂ 

Relevant academic research and scientific papers

Phenylpropenamide derivatives: Anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs

Phenylpropenamides have been reported to be a class of non-nucleoside inhibitors of the hepatitis B virus (HBV). This class of compounds was explored with the objective of developing potent anti-HBV agents, with a novel mechanism of action, that could be combined with nucleos(t)ide analogs currently used to treat HBV infection. To accomplish this objective a series of substituted arylpropenamide derivatives were prepared and the E and Z geometrical isomers were separated. The structural identity of each of the E and Z isomers was determined by single crystal X-ray crystallography. Contrary to previous reports, the activity of this class of molecules resides in the Z isomer. Further structure-activity relationship studies around the active Z isomer identified compounds that displayed potent antiviral activity against HBV with EC90 value of approximately 0.5 μM in vitro. Attempts to develop ring constrained analogs did not lead to active HBV inhibitors.

Aryl-heteroaromatic products, compositions comprising them and use

Aryl-heteroaromatic products, compositions comprising them and use. The present invention relates to novel chemical compounds, particularly to novel aryl-heteroaromatic products, to compositions comprising them, and to their use as medicaments, in particu