80223-51-4

Upstream product

• 934-72-5 Methyl p-tolyl sulfoxide 
• 105-37-3 Ethyl propionate 

Downstream Products

• 136613-29-1 1-[(R)-1-((S)-Toluene-4-sulfinylmethyl)-propyl]-piperidine 
• 136613-28-0 1-[(S)-1-((S)-Toluene-4-sulfinylmethyl)-propyl]-piperidine 

Relevant academic research and scientific papers

The preparation of optically active β-keto sulfoxides by the reaction of α-lithiomethyl p-tolyl sulfoxide with ethyl carboxylates in the presence of (-)-sparteine

Treatment of 2 equivalents of racemic α-lithiomethyl p-tolyl sulfoxide (1) with ethyl carboxylates (2, C2H5O-CO-R) possessing a variety of groups R in the presence of (-)-sparteine afforeded the corresponding optically active β-keto sulfoxides (3, p-CH3C6