80223-79-6

Basic information

• Product Name: 5-ACETONYL-2-METHOXYBENZENESULPHONYLCHLORIDE
• Synonyms: 5-ACETONYL-2-METHOXYBENZENESULPHONYLCHLORIDE
• CAS NO: 80223-79-6
• Molecular Formula: C₁₀H₁₁ClO₄S
• Molecular Weight: 262.71
• Mol File: 80223-79-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-ACETONYL-2-METHOXYBENZENESULPHONYLCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ACETONYL-2-METHOXYBENZENESULPHONYLCHLORIDE(80223-79-6)
• EPA Substance Registry System: 5-ACETONYL-2-METHOXYBENZENESULPHONYLCHLORIDE(80223-79-6)

Safety Data

• Hazardous Substances Data: 80223-79-6(Hazardous Substances Data)

Upstream product

• 122-84-9 4-methoxybenzyl methyl ketone 

Downstream Products

• 125960-41-0 1-[4-Methoxy-3-(piperidine-1-sulfonyl)-phenyl]-propan-2-one 
• 125960-43-2 1-[4-Methoxy-3-(morpholine-4-sulfonyl)-phenyl]-propan-2-one 
• 125960-57-8 1-[4-Methoxy-3-(thiomorpholine-4-sulfonyl)-phenyl]-propan-2-one 
• 125960-42-1 1-[4-Methoxy-3-(4-methyl-piperazine-1-sulfonyl)-phenyl]-propan-2-one 
• 144834-01-5 N-Decyl-2-methoxy-5-(2-oxo-propyl)-benzenesulfonamide 
• 144818-75-7 N-(2-Hydroxy-ethyl)-2-methoxy-5-(2-oxo-propyl)-benzenesulfonamide 
• 125960-54-5 N,N-Diethyl-2-methoxy-5-(2-oxo-propyl)-benzenesulfonamide 
• 125960-55-6 N-Butyl-2-methoxy-5-(2-oxo-propyl)-benzenesulfonamide 
• 1429624-84-9 N-(5-(3-(N-(4-hydroxyphenyl)sulfamoyl)-4-methoxyphenyl)-4-methylthiazol-2-yl)cyclopentanecarboxamide 
• 1881233-39-1 N-(5-(3-(N-(4-hydroxyphenyl)sulfamoyl)-4-methoxyphenyl)-4-methylthiazol-2-yl)pivalamide 
• 144818-76-8 N-Benzyl-2-methoxy-5-(2-oxo-propyl)-benzenesulfonamide 
• 80223-78-5 4-methoxy-3-N,N-dimethylsulfamylphenylacetone 
• 144818-77-9 N,N-Dihexyl-2-methoxy-5-(2-oxo-propyl)-benzenesulfonamide 
• 144818-74-6 2-Methoxy-N-octyl-5-(2-oxo-propyl)-benzenesulfonamide 

Relevant articles and documents

Method of resolving tamsulosin enantiomer

The invention relates to a method of resolving tamsulosin enantiomer, and in particular, relates to a method of resolving tamsulosin, represented as the formula (I), into an R-enantiomer and an S-enantiomer. The method includes the steps of: (a) dissolving a solid mixture of (R)-tamsulosin free alkali and (S)-tamsulosin free alkali in a solvent and performing a reaction to the free alkalis with camphor-10-sulfonic acid to form a solution containing a pair of diastereomeric camphor-10-sulfonates of tamsulosin, and then preferentially precipitating one diastereomeric camphor-10-sulfonate of the tamsulosin from the solution containing a pair of the diastereomeric camphor-10-sulfonates of tamsulosin, thereby forming a precipitate, in which one diastereomer is enriched, and a solute, in which the other one diastereomer is enriched; and (b) from one of the precipitate and the solute, releasing tamsulosin free alkali to obtain optical-rotation-enriched tamsulosin free alkali. The method has excellent technical performance.

2-Alkyloxazoles as potent and selective PI4KIIIβ inhibitors demonstrating inhibition of HCV replication

Synthesis and SAR of 2-alkyloxazoles as class III phosphatidylinositol-4-kinase beta (PI4KIIIβ) inhibitors is described. These compounds demonstrate that inhibition of PI4KIIIb leads to potent inhibition of HCV replication as observed in genotype (GT) 1a

A METHOD OF PREPARATION OF (R)-(-)-5(2-AMINOPROPYL)-2-METHOXYBENZENESULFONAMIDE

A method of preparation of (R)-(-)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide of formula I and its use for production tamsulosin. A protective group is introduced to N-[(1R)-2-(4-methoxyphenyl)-1-methylethyl]-N- [(1 R)-1-phenylethyl)]amine and the resulting amide of formula IX is chlorosulfonated and the resulting sulfochloride is converted to a sulfonamide of formula X, from which the compound of formula I is obtained by hydrogenation.