80224-82-4Relevant academic research and scientific papers
Synthesis of new tetracyclic paullone derivatives as potential CDK inhibitors
Koutsandrea, Efthimia G.,Fousteris, Manolis A.,Nikolaropoulos, Sotiris S.
, p. 169 - 179 (2012)
Synthetic efforts towards new tetracyclic heterocycles bearing the pyrrolo[2',3':5,6]azepino[4,3- b ] indol-4(11 H )-one core are described. Synthesized tetracyclic compounds are the first analogs, structurally related to protein kinase inhibitors paullones which incorporate an azepinone, an indole and a pyrrole ring. The synthetic approach involves palladium mediated intramolecular Heck coupling as a key step.
Intramolecular oxidative C-H coupling for medium-ring synthesis
Pintori, Didier G.,Greaney, Michael F.
supporting information; experimental part, p. 1209 - 1211 (2011/04/16)
An oxidative C-H coupling is described for medium-ring synthesis.
Synthesis of 2,5-Disubstituted Oxazoles from Aldehydes and N-(Tosylmethyl)imino Synthons. Application to the Synthesis of Pimprinine Analogues
Houwing, Hendrik A.,Wildeman, Jurjen,van Leusen, Albert M.
, p. 1133 - 1139 (2007/10/02)
A series of N-(tosylmethyl)imino compounds has been applied to a new base induced, one-operational synthesis of 2,5-disubstituted oxazoles from aromatic aldehydes.For substituent A of the imino compounds, which becomes the 2-substituent in the oxazoles, has been chosen methoxy, methyl and phenyl.The new method has been used also to synthesize seven pimprinine analogues, i.e., 5-(3-indolyl)oxazoles.
