80224-89-1

Basic information

• Product Name: 5-(4-chlorophenyl)-2-phenyl-1,3-oxazole
• Synonyms: 5-(4-chlorophenyl)-2-phenyl-1,3-oxazole
• CAS NO: 80224-89-1
• Molecular Weight: 255.703
• Mol File: 80224-89-1.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 5-(4-chlorophenyl)-2-phenyl-1,3-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chlorophenyl)-2-phenyl-1,3-oxazole(80224-89-1)
• EPA Substance Registry System: 5-(4-chlorophenyl)-2-phenyl-1,3-oxazole(80224-89-1)

Safety Data

• Hazardous Substances Data: 80224-89-1(Hazardous Substances Data)

Upstream product

• 5468-33-7 1-(4-chlorophenyl)-2-nitroethan-1-one 
• 707-07-3 orthobenzoic acid trimethyl ester 
• 1073-67-2 4-vinylbenzyl chloride 
• 100-46-9 benzylamine 
• 3418-95-9 1-(benzoylamino)-2-(4-chlorophenyl)ethane 
• 99-91-2 para-chloroacetophenone 
• 2835-06-5 phenylglycin 
• 873-73-4 4-n-chlorophenylacetylene 
• 61650-22-4 N-(pivaloyloxy)benzamide 
• 622-79-7 benzyl azide 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 55-21-0 benzamide 
• 66482-29-9 1-[(E)-2-bromoethenyl]-4-chlorobenzene 
• 1393689-82-1 (E)-N-(4-chlorostyryl)benzamide 

Relevant articles and documents

Synthesis of 2,5-Disubstituted Oxazoles from Arylacetylenes and α-Amino Acids through an i 2 /Cu(NO 3) 2 ?3H 2 O-Assisted Domino Sequence

A new strategy has been developed for the synthesis of 2,5-disubstituted oxazoles from easily available arylacetylenes and α-amino acids in the presence of Cu(NO 3) 2 ?3H 2 O and iodine. This reaction process involves the I 2 /Cu(NO 3) 2 ?3H 2 O-assisted transformation of arylacetylene to α-iodo acetophenone, Kornblum oxidation to phenylglyoxal, condensation to imine, decarboxylation/annulation/oxidation reaction sequence to approach 2,5-disubstituted oxazoles.

Synthesis of 2,5-disubstituted oxazoles: Via cobalt(III)-catalyzed cross-coupling of N -pivaloyloxyamides and alkynes

An efficient synthesis of 2,5-disubstituted oxazoles via Co(iii) catalysis is described herein. The synthesis is achieved under mild conditions through [3+2] cycloaddition of N-pivaloyloxyamides and alkynes. The reaction operates through an internal oxidation pathway and features a very broad substrate scope. The one-step synthesis of natural products such as texamine and balsoxin has been demonstrated via this protocol.

N -Bromosuccinimide as a Brominating Agent for the Transformation of N -H (or N -Benzyl) Ketoaziridines into Oxazoles

A novel procedure for the direct synthesis of 2,5-diaryloxazoles starting from N-H ketoaziridines is described. The method proceeds via the in situ formation of N-bromoketoaziridines in the presence of N-bromosuccinimide followed by the generation of intermediate azomethine ylides. A plausible mechanism for this transformation is proposed.