80226-91-1

Basic information

• Product Name: 10,10-difluoro-13-dehydroprostacyclin
• Synonyms: 10,10-difluoro-13-dehydroprostacyclin
• CAS NO: 80226-91-1
• Molecular Formula: C20H28 F2 O5
• Molecular Weight: 386.44
• Mol File: 80226-91-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 572.5°C at 760 mmHg
• Flash Point: 300°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 1.72E-15mmHg at 25°C
• Refractive Index: 1.534
• CAS DataBase Reference: 10,10-difluoro-13-dehydroprostacyclin(CAS DataBase Reference)
• NIST Chemistry Reference: 10,10-difluoro-13-dehydroprostacyclin(80226-91-1)
• EPA Substance Registry System: 10,10-difluoro-13-dehydroprostacyclin(80226-91-1)

Safety Data

• Hazardous Substances Data: 80226-91-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H28F2O5/c1-2-3-4-7-13(23)10-11-15-16-12-14(8-5-6-9-17(24)25)27-19(16)20(21,22)18(15)26/h8,13,15-16,18-19,23,26H,2-7,9,12H2,1H3,(H,24,25)/b14-8-/t13-,15+,16+,18-,19-/m0/s1

Relevant articles and documents

Method for preparing 10,10-difluoro prostacyclins

A method is provided for preparing compounds of the formulae STR1 wherein A may be --C=C-- or --C C--, by reducing an epoxy lactone of the structure STR2 to form the corresponding epoxy hemiacetal, reacting the epoxy hemiacetal with a silyl compound to form an epoxy silyl acetal, reacting the epoxy silyl acetal with an acetylenic derivative to form a silyl acetal, removing the silyl protecting group to form a hemiacetal, reacting the hemiacetal compound with an appropriate Wittig reagent to form a protected difluoro PGF2α type compound, removing the protecting group, reacting the difluoro PGF2α with an iodine compound to form an iodoether and reacting the iodoether with a base to form the desired compounds. The compounds may be used, e.g., to prevent the aggregation of blood platelets. Novel intermediates produced in the above method are also provided.