80235-73-0

Basic information

• Product Name: Formamide, N-[1-(3,4-dimethoxyphenyl)-2-phenylethyl]-
• CAS NO: 80235-73-0
• Molecular Formula: C17H19NO3
• Molecular Weight: 285.343
• Mol File: 80235-73-0.mol

Chemical Properties

• CAS DataBase Reference: Formamide, N-[1-(3,4-dimethoxyphenyl)-2-phenylethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Formamide, N-[1-(3,4-dimethoxyphenyl)-2-phenylethyl]-(80235-73-0)
• EPA Substance Registry System: Formamide, N-[1-(3,4-dimethoxyphenyl)-2-phenylethyl]-(80235-73-0)

Safety Data

• Hazardous Substances Data: 80235-73-0(Hazardous Substances Data)

Upstream product

• 3141-93-3 4',5'-dimethoxydeoxybenzoin 
• 77287-34-4 formamide 

Downstream Products

• 135365-15-0 5-(3,4-Dimethoxy-phenyl)-6,10b-dihydro-5H-oxazolo[2,3-a]isoquinoline-2,3-dione 
• 135365-25-2 3,4-dihydro-3-(3,4-dimethoxyphenyl)isoquinoline 
• 3892-92-0 (E)-3,4-dimethoxystilbene 
• 121682-35-7 N-<1-(3,4-dimethoxyphenyl)-2-phenylethyl>phenylacetamide 
• 80235-75-2 2-phenyl-1-(3,4-dimethoxyphenyl)ethyl amine 

Relevant articles and documents

Towards the rehabilitation of the Leuckart reductive amination reaction using microwave technology

Leuckart reductive amination of carbonyl compounds was dramatically enhanced with respect to conventional heating by a specific microwave effect when the reaction was performed, under solvent-free conditions, in a monomode microwave reactor. Excellent iso

Catecholamine surrogates useful as β3 agonists

Compounds of the formula STR1 or pharmaceutically acceptable salts thereof wherein: A is a bond, --(CH 2) n -- or --CH(B)--, where n is an integer of 1 to 3 and B is --CN, --CON(R 9)R 9'' or --CO 2 R 7 ;R 1 is lower alkyl, aryl or arylalkyl;R 2 is hydrogen, hydroxy, alkoxy, --CH 2 OH, cyano, --C(O)OR 7, --CO 2 H, --CONH 2, tetrazole, --CH 2 NH 2 or halogen; STR2 R 3 is hydrogen, alkyl, heterocycle or R 4 is hydrogen, alkyl or B;R 5, R 5'', R 8, R 8'' or R 8"" are independently hydrogen, alkoxy, lower alkyl, halogen, --OH, --CN, --(CH 2) n NR 6 COR 7, --CON(R 6)R 6'', --CON(R 6)OR 6'', --CO 2 R 6, --SR 7, --SOR 7, --SO 2 R 7, --N(R 6)SO 2 R 1, --N(R 6)R 6'', --NR 6 COR 7, --OCH 2 CON(R 6)R 6'', --OCH 2 CO 2 R 7 or aryl; orR 5 and R 5'' or R 8 and R 8'' may together with the carbon atoms to which they are attached form an aryl or heterocycle;R 6 and R 6'' are independently hydrogen or lower alkyl; andR 7 is lower alkyl;R 9 is hydrogen, lower alkyl, alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl; or R 9 and R 9'' may together with the nitrogen atom to which they are attached form a heterocycle; with the proviso that when A is a bond or --(CH 2) n and R 3 is hydrogen or unsubstituted alkyl, then R 4 is B or substituted alkyl. These compounds are beta 3 adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity and gastrointestinal diseases.

Application of the intramolecular ?-amidoalkylation reaction for the synthesis of 3- and 1,3-alkyl(aryl) 2-formyltetrahydroisoquinolines

3- and 1,3-alkyl(aryl) 2-formyltetrahydroisoquinolines 6 are obtained by the application of the intramolecular ?-amidoalkylation reaction from 1-alkyl(aryl)-2-arylethylformamides 2 and aldehydes in acidic medium.

A Modified Bischler-Napieralski Procedure for the Synthesis of 3-Aryl-3,4-dihydroisoquinolines

A modification of the Bischler-Napieralski reaction for the cyclization of (1,2-diphenylethyl)amides to the 3-aryl-3,4-dihydroisoquinolines is presented.Elimination of the amide group as the nitrile via the retro-Ritter reaction is avoided by its conversion to an N-acyliminium intermediate with oxalyl chloride-FeCl3.Removal of the oxalyl group in refluxing MeOH-sulfuric acid provides the 3,4-dihydroisoquinolines in moderate to high yields.The method is also highly effective with (2-phenylethyl)amides.