80238-36-4Relevant academic research and scientific papers
A cascade synthesis of aminohydantoins using in situ-generated N-substituted isocyanates
Vincent-Rocan, Jean-Franois,Clavette, Christian,Leckett, Kyle,Beauchemin, Andr M.
, p. 3886 - 3890 (2014)
Nitrogen-substituted isocyanates are rarely utilized but powerful building blocks for the development of cascade reactions in heterocyclic synthesis. These reactive amphoteric intermediates can be accessed in situ via an equilibrium that allows controlled reactivity in the presence of bifunctional partners such as a-amino esters. A cascade reaction has been carried out that forms 3-aminohydantoin derivatives using simple phenoxycarbonyl derivatives of hydrazides and hydrazones as precursors of Nsubstituted-isocyanates. This method allows rapid assembly of complex aminohydantoin derivatives, including analogues of medicinally-relevant compounds, using simple reactants.
Acetylenic Ketones. 8. Synthesis and Spectroscopic Studies of Some Hydrazones
Baddar, Fawzi G.,Al-Hajjar, Farouk H.,El-Rayyes, Nizar R.
, p. 213 - 217 (2007/10/02)
Aroylphenylacetylenes, benzaldehydes, and acetophenones reacted with ethyl and phenyl hydrazinecarboxylates to give the corresponding hydrazone N-carboxylic esters of ω-aroylacetophenone (IIIa-f), benzaldehyde (IXa-f), and acetophenone (IXg-l).UV, IR, and
