80240-38-6

Basic information

• Product Name: 4-(3-Chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
• Synonyms: 4-(3-Chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
• CAS NO: 80240-38-6
• Molecular Formula: C₈H₆ClN₃O
• Molecular Weight: 195.60574
• Mol File: 80240-38-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(3-Chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-Chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one(80240-38-6)
• EPA Substance Registry System: 4-(3-Chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one(80240-38-6)

Safety Data

• Hazardous Substances Data: 80240-38-6(Hazardous Substances Data)

Upstream product

• 51707-42-7 N-(3-chlorophenyl)hydrazine carboxamide 
• 3473-63-0 formamidine acetic acid 

Downstream Products

• 1346235-53-7 1-(3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl) piperazin-1-yl)propyl)-4-(3-chlorophenyl)-1H-1,2,4-triazol-5(4H)-one 
• 1346235-33-3 C₁₅H₂₀ClN₅O 
• 1346235-13-9 C₁₁H₁₁BrClN₃O 

Relevant articles and documents

Design and synthesis of novel triazole antifungal derivatives by structure-based bioisosterism

The incidence of life-threatening fungal infections is increasing dramatically. In an attempt to develop novel antifungal agents, our previously synthesized phenoxyalkylpiperazine triazole derivatives were used as lead structures for further optimization. By means of structure-based bioisosterism, triazolone was used as a new bioisostere of oxygen atom. This type of bioisosteric replacement can improve the water solubility without loss of hydrogen-bonding interaction with the target enzyme. A series of triazolone-containing triazoles were rationally designed and synthesized. As compared with fluconazole, several compounds showed higher antifungal activity with broader spectrum, suggesting their potential for further evaluations.