80242-21-3Relevant academic research and scientific papers
Silver-Promoted (4 + 1) Annulation of Isocyanoacetates with Alkylpyridinium Salts: Divergent Regioselective Synthesis of 1,2-Disubstituted Indolizines
Chen, Yan,Shatskiy, Andrey,Liu, Jian-Quan,K?rk?s, Markus D.,Wang, Xiang-Shan
supporting information, p. 7555 - 7560 (2021/10/02)
An unprecedented silver-promoted regioselective (4 + 1) annulation of isocyanoacetates with pyridinium salts is reported. The established protocol provides controlled, facile, and modular access to a range of synthetically useful N-fused heterocyclic scaffolds containing indolizines, pyrrolo[1,2-a]quinolines, pyrrolo[2,1-a]isoquinolines, and 1H-imidazo[4,5-a]indolizin-2(3H)-ones. A mechanistic pathway involving nucleophilic addition/protonation/elimination/cycloisomerization is proposed.
Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. Part 1: Structure-activity relationships of the 1- and 3-positions
Kemnitzer, William,Kuemmerle, Jared,Jiang, Songchun,Zhang, Han-Zhong,Sirisoma, Nilantha,Kasibhatla, Shailaja,Crogan-Grundy, Candace,Tseng, Ben,Drewe, John,Cai, Sui Xiong
scheme or table, p. 6259 - 6264 (2009/07/18)
1-Benzoyl-3-cyanopyrrolo[1,2-a]quinoline (2a) was identified as a novel apoptosis inducer through our caspase- and cell-based high-throughput screening assay. Compound 2a had good activity against several breast cancer cell lines but was much less active
APOPTOSIS INHIBITORS
-
Page/Page column 22, (2010/11/23)
The present invention provides compounds that act as selective agents to protect against unintentional cell death or tissue damage and can relieve side effects of cancer treatment such as, for example, oral mucositis, hair loss, diarrhea due to damage to
Quinolinium salt as a potent inhibitor of lymphocyte apoptosis
Barchechath, Sylvie D.,Tawatao, Rommel I.,Corr, Maripat,Carson, Dennis A.,Cottam, Howard B.
, p. 1785 - 1788 (2007/10/03)
The synthesis of several quinolinium salts and related compounds and their ability to inhibit glucocorticoid-induced apoptosis in murine thymocytes are described. Interestingly, 1-[2-methoxyimino-2-(4-pyrrolidin-1-yl-phenyl)ethyl] quinolinium bromide (11) showed a potent protective effect with an EC 50 of 0.013 μM, which was at least 300-fold more potent than the reference compound pifithrin-α.
Syntheses and cytotoxic, antimicrobial, antifungal and cardiovascular activity of new quinoline derivatives
Khan,Saify,Khan,Ahmed,Saeed,Schick,Kohlbau,Voelter
, p. 915 - 924 (2007/10/03)
New derivatives of quinoline (CAS 91-22-5, Z-1) were synthesized and their potential therapeutical significance and structure-activity relationship were tested. The brine shrimp bioassay was carried out to study their in vitro cytotoxicity, and besides, a
1-(acylaminomethyl)imidazo(1,2-A)quinoline derivatives, their preparation and their application in therapy
-
, (2008/06/13)
A compound which is a 1-acylaminomethylimidazo[1,2-a]quinoline of formula (I) STR1 in which A and B both denote hydrogen or together denote a direct carbon-carbon bond, X denotes hydrogen or a halogen or a (C1-4)alkyl, (C1-4)alkoxy,
