80246-27-1 Usage
Biological functions
Reduced serum thyroxine levels and thyroid follicular cell hyperplasia were observed in rats and mice orally exposed to lower brominated PBDE mixtures.PBDE congeners BDE-19 and -10 inhibit AR binding.BDE-99?treatment during pregnancy reduced the estradiol-17β and testosterone levels in male offspring in rats,and affected the progesterone and estrogen receptor (ER)-α and -β levels in the uterus of female offspring.
Description
PBDEs are organobromine compounds used as flame retardants, and they show antiandrogenic and antithyroid activities.
Physical properties
Molecular formula C12H(10- x)BrxO. Soluble in acetone and benzene.
Check Digit Verification of cas no
The CAS Registry Mumber 80246-27-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,2,4 and 6 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 80246-27:
(7*8)+(6*0)+(5*2)+(4*4)+(3*6)+(2*2)+(1*7)=111
111 % 10 = 1
So 80246-27-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H4Br6O3/c13-3-1-4(14)10(19)5(2-3)21-12-9(18)7(16)6(15)8(17)11(12)20/h1-2,19-20H
80246-27-1Relevant articles and documents
Antibacterial compounds and uses thereof
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Page/Page column 9-10, (2008/06/13)
The invention relates to antibacterial compounds and their use to treat bacterial infections. More particularly, the invention relates to substituted biphenyl compounds having antibacterial activity. The invention provides methods for treating bacterial infections using PBDEs that have not previously been used to treat bacterial infections. The invention further provides novel PBDEs that are useful in such methods.
