80253-79-8Relevant academic research and scientific papers
The Zincke's reaction: A new alternative for the preparation of 1-[2- (3-indol)ethyl]-alkylpyridinium chloride derivatives
Gnecco, Dino,Juarez, Jorge,Galindo, Alberto,Marazano, Christian,Enriquez, Raul G.
, p. 281 - 287 (2007/10/03)
The Zincke's salts 3 (a-f) were prepared and used for the synthesis of 1-[(2-(3-indol)-ethyl]alkylpyridinium chloride derivatives 5 (a-f) in high yields.
N.c.a. 11C-labelling of benzenoid compounds in ring positions: Synthesis of 3-nitro-[3-11C]toluene and 4-nitro-[4-11C]toluene and their corresponding toluidines
Maeding,Steinbach
, p. 647 - 656 (2007/10/03)
The paper describes the syntheses of n.c.a. 3-nitro-[3-11C]toluene (3a) and 4-nitro-[4-11C]toluene (3b) by reaction of nitro-[11C]methane (1) with 5-dimethylamino-2(or 3)-methyl-penta-2,4-dienylidene- dimethylammonium tetr
A Stereocontrolled Alkylation of Chiral Pyridinium Salts with Grignard Reagents: Synthesis of (+)-Normetazocine and (+)-Nordextrorphan
Genisson, Yves,Marazano, Christian,Das, Bhupesh C.
, p. 2052 - 2057 (2007/10/02)
The synthesis of chiral pyridinium salts 3, bearing lipophilic counteranions, is described.These salts, soluble in THF or toluene, undergo nucleophilic alkylation with benzylic Grignard reagents to give, after reduction of the unstable dihydropyridine int
DERIVATIVES AND REACTIONS OF GLUTACONALDEHYDE-XIII. REGIOSPECIFIC RING OPENING OF 3-SUBSTITUTED PYRIDINES
Becher, Jan,Finsen, Lars,Winckelmann, Ib
, p. 2375 - 2378 (2007/10/02)
A number of nucleophilic ring openings of 3-substituted pyridinium salts have been reinvestigated and summarized.The structure of the resulting stable glutaconaldehyde derivatives was investigated in detail by 1H NMR.It has been concluded that in general nucleophilic pyridinium ring openings are highly regiospecific.In each case investigated to date a single product was isolated, as a result of attack by the nucleophile at only one of the pyridine α-positions.With the OH ion as the only nucleophile, attack occurs at the pyridine C-2, while larger nucleophiles such as amines and carbanions attack at the pyridine C-6.This was found to be the case for a variety of 3-substituted pyridines such as 3-methyl-, 3-methoxy-, 3-cyano-, 3-chloro-pyridine.
