80254-87-1

Basic information

• Product Name: Methyl 4'-fluorobiphenyl-4-carboxylate
• Synonyms: Methyl 4'-fluorobiphenyl-4-carboxylate;[1,1'-Biphenyl]-4-carboxylic acid, 4'-fluoro-, Methyl ester
• CAS NO: 80254-87-1
• Molecular Formula: C₁₄H₁₁FO₂
• Molecular Weight: 230.2343432
• Mol File: 80254-87-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl 4'-fluorobiphenyl-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4'-fluorobiphenyl-4-carboxylate(80254-87-1)
• EPA Substance Registry System: Methyl 4'-fluorobiphenyl-4-carboxylate(80254-87-1)

Safety Data

• Hazardous Substances Data: 80254-87-1(Hazardous Substances Data)

Upstream product

• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 1194-02-1 4-fluorobenzonitrile 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 4363-35-3 Dihydroxy-styryl-boran 

Downstream Products

• 644-08-6 4-Methylbiphenyl 
• 147497-56-1 (4'-Fluoro-biphenyl-4-yl)-methanol 
• 5731-10-2 4'-fluoro-biphenyl-4-carboxylic acid 

Relevant articles and documents

A Radical Chain: Mononuclear “Gold Only” Photocatalysis

We herein report an unprecedented reactivity of mononuclear gold catalysts acting as classical catalysts and at the same time as active partners in a radical chain mechanism, whereby gold is the only catalyst. The mechanism of the photo-induced photosensitizer-free “gold only”-catalyzed cross coupling was studied in detail – experimentally and theoretically – based on the reaction between arylboronic acids and aryldiazonium salts. With a systematic set of stoichiometric experiments under various conditions and analytic methods, we could show that this mechanism is initiated by an aryl radical formed in the presence of blue LEDs and MeOH. This aryl radical enters the catalytic cycle to oxidize gold(I) to gold(II). Single electron transfer from gold(II) to the aryldiazonium salt then gives the cationic gold(III) complex by formation of a chain-supporting aryl radical which then is enabled to start a new cycle by oxidation of gold(I) without the need for irradiation. At least every 432 cycles of the radical chain, a new chain-initiating radical has to restart the radical chain. Eventually, the boronic acid is activated by the BF4? anion to transmetalate to gold(III), and reductive elimination delivers the desired product.

para-Selective arylation and alkenylation of monosubstituted arenes using thianthreneS-oxide as a transient mediator

Using thianthreneS-oxide (TTSO) as a transient mediator,para-arylation and alkenylation of mono-substituted arenes have been demonstratedviaapara-selective thianthrenation/Pd-catalyzed thio-Suzuki-Miyaura coupling sequence under mild conditions. This reaction features a broad substrate scope, and functional group and heterocycle tolerance. The versatility of this approach was further demonstrated by late-stage functionalization of complex bioactive scaffolds, and direct synthesis of some pharmaceuticals, including Tetriprofen, Ibuprofen, Bifonazole, and LJ570.

N-acylsulfonamide apoptosis promoters

N-Benzoyl arylsulfonamides having the formula are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.