80263-03-2Relevant articles and documents
Synthesis of Large-Ring Analogues of Estrone by a Ring-Expansion Route
Thies, Richard W.,Pierce, John R.
, p. 798 - 803 (2007/10/02)
A synthetic methodology is described wherein a sequence of three ring expansions is used to convert cycloheptanone to 4'-methoxy-5,6-benzocyclodecenone, which was tested for estrogenic properties but showed no uterotrophic activity.Attempts to selectively expand the large ring by one more carbon to 8,9:13,14-diseco-18-norestrone were not successful.