Metoprolol fumarate is a pharmaceutical compound that functions as a β-adrenoceptor antagonist, commonly used in the treatment of cardiovascular conditions. It is a synthetic, racemic mixture of two enantiomers, Dand L-metoprolol, which selectively target β1-adrenergic receptors in the heart, leading to a reduction in heart rate and blood pressure.
Used in Pharmaceutical Industry:
Metoprolol fumarate is used as an antihypertensive agent for the treatment of high blood pressure. It helps to lower blood pressure by reducing the workload on the heart and widening of blood vessels, thus improving overall cardiovascular health.
Metoprolol fumarate is also used as a heart failure treatment to manage the symptoms and prolong life in patients with chronic heart failure. Its β1-selective action helps to reduce the heart's oxygen demand while maintaining its contractility, which is crucial for patients with compromised heart function.
Furthermore, Metoprolol fumarate is utilized in the management of angina pectoris, a condition characterized by chest pain due to insufficient blood flow to the heart. By slowing the heart rate and reducing blood pressure, it decreases the oxygen demand of the heart, thereby reducing the frequency and severity of angina attacks.
In addition to these cardiovascular applications, Metoprolol fumarate is used in an oral osmotic controlled-release system (OROS) to ensure a steady and sustained release of the drug over an extended period. This advanced drug delivery system enhances the therapeutic efficacy and patient compliance by providing a once-daily dosage regimen, which maintains a consistent drug level in the bloodstream throughout the day.

80274-67-5

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Basic information
1. Product Name: Metoprolol fumarate
2. Synonyms: Metoprolol fumarate;Metoprolol hemifumarate
3. CAS NO:80274-67-5
4. Molecular Formula: C19H29NO7
5. Molecular Weight: 383.43606
6. EINECS: N/A
7. Product Categories: N/A
8. Mol File: 80274-67-5.mol
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: N/A
3. Flash Point: N/A
4. Appearance: /
5. Density: N/A
6. Refractive Index: N/A
7. Storage Temp.: -20°C Freezer, Under inert atmosphere
8. Solubility: Chloroform (Slightly), Methanol (Slightly)
9. CAS DataBase Reference: Metoprolol fumarate(CAS DataBase Reference)
10. NIST Chemistry Reference: Metoprolol fumarate(80274-67-5)
11. EPA Substance Registry System: Metoprolol fumarate(80274-67-5)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 80274-67-5(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 80274-67-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,2,7 and 4 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 80274-67:
(7*8)+(6*0)+(5*2)+(4*7)+(3*4)+(2*6)+(1*7)=125
125 % 10 = 5
So 80274-67-5 is a valid CAS Registry Number.

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