80279-10-3Relevant academic research and scientific papers
General method for preparation of allenic zinc reagents by three-carbon homologation of triorganozincates: Convergent three-component coupling of propargylic substrates, triorganozincates, and electrophilic reagents
Harada, Toshiro,Katsuhira, Takeshi,Osada, Atsushi,Iwazaki, Katsuhiro,Maejima, Keiji,Oku, Akira
, p. 11377 - 11390 (2007/10/03)
Allenic zinc reagents (R1R2C=C=C(R3)ZnL) are efficiently prepared by the reaction of propargylic substrates (R1R2C(X)C≡CH, X = MeSO2O,Cl, R2NCO2) with a variety of tri
The Silylcupration of Acetylenes: a Synthesis of Vinylsilanes
Fleming, Ian,Newton, Trevor W.,Roessler, Felix
, p. 2527 - 2532 (2007/10/02)
Bis(dimethylphenylsilyl)copper-lithium (1) reacts with hex-1-yne, propyne, acetylene itself, phenylacetylene, and hex-3-yne to give the products of syn addition of the dimethylphenylsilyl group and the copper.The resultant vinylcopper reagents react with a variety of electrophiles, such as the proton, iodine, acyl and alkyl halides, enones, and epoxides, to give vinylsilanes.With the terminal alkynes, the silyl group becomes attached with a high level of regioselectivity to the terminal carbon atom, with the result that the final products are 2,2-disubstituted vinylsilanes.
