80280-48-4Relevant academic research and scientific papers
Mesogenic D-A fluorophores based on cyanovinyl and benzothiadiazole
Zhang, Bei,Xiao, Yulong,Fang, Haipeng,Gao, Hongfei,Wang, Fuke,Cheng, Xiaohong
supporting information, p. 16709 - 16716 (2018/10/24)
A series of donor-acceptor fluorophores containing the biscyanovinyl dithienebenzothiadiazole central unit with 4-alkoxyphenyl groups at both sides were synthesized. These compounds can display smectic C and hexagonal columnar mesophases in their bulk states, and aggregate into organogels as well as cubic or needle crystals in organic solvents. These cubic or needle crystals exhibit optical waveguide behavior. Additionally, these compounds can exhibit broad absorption up to 625 nm with a narrow band gap of 1.79 eV. The fluorescence emission of these compounds in CHCl3 can be quenched upon addition of C70. Furthermore, these compounds can detect Cu2+ among a series of cations.
Inhibition of secretory phospholipase A2. 2-Synthesis and structure-activity relationship studies of 4,5-dihydro-3-(4-tetradecyloxybenzyl) -1,2,4-4H-oxadiazol-5-one (PMS1062) derivatives specific for group II enzyme
Dong, Chang-Zhi,Ahamada-Himidi, Azali,Plocki, Stephanie,Aoun, Darina,Touaibia, Mohamed,Meddad-Bel Habich, Nadia,Huet, Jack,Redeuilh, Catherine,Ombetta, Jean-Edouard,Godfroid, Jean-Jacques,Massicot, France,Heymans, Francoise
, p. 1989 - 2007 (2007/10/03)
We have recently reported the discovery of a series of specific inhibitors of human group IIA phospholipase A2 (hGIIA PLA2) to display promising in vitro and in vivo properties. Here we describe the influence of different structural modifications on the specificity and potency against hGIIA PLA2 versus porcine group IB PLA2. The SAR results, as well as the log P and pKa values of oxadiazolone determined in this work, provide important information towards the comprehension of the mode of action of this kind of compounds.
