802908-23-2

Upstream product

• 802908-22-1 [3,5-bis-(tetrahydro-pyran-2-yloxymethyl)-phenoxy]-acetic acid ethyl ester 
• 182629-25-0 5-{[(1,1-dimethylethyl)dimethylsilyl]oxy}benzene-1,3-dimethanol 
• 802908-21-0 3,5-bis-(tetrahydro-pyran-2-yloxymethyl)-phenol 
• 802908-20-9 [3,5-bis-(tetrahydro-pyran-2-yloxymethyl)-phenoxy]-tert-butyl-dimethyl-silane 

Downstream Products

• 802908-26-5 (3,5-bis-cyclohexylsulfanylmethyl-phenoxy)-acetic acid ethyl ester 
• 802908-25-4 (3,5-bis-phenylsulfanylmethyl-phenoxy)-acetic acid ethyl ester 
• 802908-27-6 (3,5-bis-tert-butylsulfanylmethyl-phenoxy)-acetic acid ethyl ester 
• 802908-28-7 (3,5-bis-ethylsulfanylmethyl-phenoxy)-acetic acid ethyl ester 
• 802908-24-3 (3,5-bis-bromomethyl-phenoxy)-acetic acid ethyl ester 

Relevant academic research and scientific papers

Experimental design and the optimization of a polymer supported palladium complex for use in the Heck reaction

Using a Design of Experiments approach the optimization of a Heck reaction catalyzed by a solid-supported sulfur-containing palladacycle was improved from 30% with large observable leaching to 88% with no observable leaching. Optimization of the Heck reaction of 4-bromoacetophenone with styrene by a polymer supported, sulfur-containing palladacycle, varying 6 factors at a total of 28 different levels, corresponding to 5760 different possibilities was undertaken. Conversion improved from 34%, with large observable leaching to 88% with no leaching. This was accomplished using a Design of Experiments approach facilitated by the Statistical Design Package, MODDE 7.0TM.