802910-82-3

Upstream product

• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 670276-76-3 2-(4-isopropylphenyl)-5-[(1E)-3-oxoprop-1-en-1-yl]-2H-tetrazole 

Downstream Products

• 802910-86-7 (2E,4E)-5-[2-(4-isopropylphenyl)-2H-tetrazol-5-yl]penta-2,4-dienamide 
• 802910-84-5 (2E,4E)-5-[2-(4-isopropylphenyl)-2H-tetrazol-5-yl]penta-2,4-dienoic acid 

Relevant academic research and scientific papers

New preparative route to hetaryldienes and azadienes

Tetrazolylacroleins easily available via a four step pathway from 2-aminopyridines proved to be suitable starting compounds for preparation of new tetrazolyldiene systems. Reaction with reagents containing active methylene group gave a series of new dienes, whereas hydroxylamines yielded nitrones. The new dienes underwent cyclizations with electron withdrawn dienophiles to yield tetrazolyl substituted new polycycles, and the nitrones gave fused isoxazolines. The electron demand of the tetrazolyldienes in cycloadditions was interpreted by calculation of frontier orbital energy levels.