802915-53-3

Upstream product

• 800391-43-9 (R)-[3-(5-amino-2,2-dimethyl-4-oxo-chroman-6-yl)-1-hydroxymethyl-3-oxo-propyl]-carbamic acid tert-butyl ester 
• 800391-40-6 5-amino-2,2-dimethyl-chroman-4-one 

Relevant academic research and scientific papers

Concise synthesis of fungal metabolite (+)-fusarochromanone via rhodium(III)-catalyzed oxidative sp2 C-H bond olefination

The concise synthesis of a fungal metabolite, (+)-fusarochromanone (FC-101), was achieved via the oxidative sp2 C-H bond olefination of an N-acetylaminochromanone with a chiral functionalized electron-rich alkene, catalyzed by an electron-deficient (η5-cyclopentadienyl)rhodium(III) complex, [CpERhCl2]2, under ambient conditions as the key step. This protocol was applied to various acetanilides and functionalized electron-rich alkenes for the syntheses of fusarochromanone analogs.

SYNTHESIS OF CHROMANONES

Processes for the preparation of biologically active chromanones are disclosed, including processes for the preparation of intermediates useful in the preparation of the biologically active chromanones. The chromanones and the intermediates disclosed herein may be useful for a variety of therapies, including the treatment of various cancers and the treatment of inflammation and inflammation related disorders.