802918-36-1 Usage
Uses
Used in Pharmaceutical Industry:
Cinacalcet IMpurity 9 is used as a reference material for quality control and analytical purposes in the development and manufacturing processes of cinacalcet and its congeners. Its enantiomerically pure nature ensures accurate assessment and comparison during the synthesis, purification, and characterization of the target compounds.
Used in Research and Development:
Cinacalcet IMpurity 9 serves as a valuable research tool for studying the structural and functional differences between enantiomers and their potential impact on the pharmacological properties of cinacalcet and related compounds. This understanding can contribute to the optimization of drug design and the development of more effective therapeutic agents.
Used in Regulatory Compliance:
Cinacalcet IMpurity 9 is utilized in the context of regulatory compliance, where it is necessary to demonstrate the purity and quality of the active pharmaceutical ingredient (API) and its related substances. This helps ensure that the final drug product meets the required safety, efficacy, and quality standards set by regulatory authorities.
Check Digit Verification of cas no
The CAS Registry Mumber 802918-36-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,0,2,9,1 and 8 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 802918-36:
(8*8)+(7*0)+(6*2)+(5*9)+(4*1)+(3*8)+(2*3)+(1*6)=161
161 % 10 = 1
So 802918-36-1 is a valid CAS Registry Number.
802918-36-1Relevant academic research and scientific papers
Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis
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Page/Page column 44; 52, (2008/06/13)
The present invention relates to novel dihydronaphthalene compounds, compositions, methods for using the same, and processes for preparing the same. The present invention also relates to novel total synthesis approaches for preparing these compounds. In addition, the present invention relates to methods of producing quantities of isomers of these compounds and separating and purifying them using chiral separation techniques. The present invention also relates to methods of producing quantities of a single isometric compound without the need for chiral separation techniques.
Synthesis of Cinacalcet congeners
Wang, Xin,Chen, Ying,Crockett, Richard,Briones, Jorge,Yan, Tony,Orihuela, Carlos,Zhi, Benxin,Ng, John
, p. 8355 - 8358 (2007/10/03)
Two related substances 1 and 2 of Cinacalet were prepared. Two racemic isomeric dihydronaphthalenes 1 and 2 were prepared from commercially available 5-hydroxytetralone in five linear steps. A key palladium-catalyzed double bond migration led to the synthesis of both isomers from the same starting material. Preparative chiral HPLC separation provided the enantiomerically pure materials. An asymmetric synthesis employing CBS reduction to furnish 1 was also developed.
