80295-38-1 Usage
Description
C1 Esterase Inhibitor, also known as C1 INH, is a single chain glycoprotein that plays a crucial role in the regulation of the immune and blood clotting systems. It is a member of the serpin family and is present in the plasma at concentrations of 16-33 mg/100mL. C1 Esterase Inhibitor inhibits various enzymes, including C1, C1r, C1s, plasma kallikrein, factors XIa, XIIa, and plasmin, thereby maintaining the balance between pro-inflammatory and anti-inflammatory responses in the body.
Uses
Used in Hereditary Angioedema Treatment:
C1 Esterase Inhibitor is used as a therapeutic agent for the treatment of hereditary angioedema (HAE), a rare genetic disorder characterized by recurrent episodes of swelling in various parts of the body, including the face, abdomen, and extremities. The condition is caused by a deficiency or dysfunction of C1 INH, leading to uncontrolled activation of the complement and contact systems. By administering C1 Esterase Inhibitor, the activity of the affected enzymes is regulated, reducing inflammation and alleviating symptoms.
Used in Inflammatory Diseases:
C1 Esterase Inhibitor is also used as an anti-inflammatory agent for various inflammatory conditions. Its ability to inhibit multiple enzymes involved in the inflammatory process makes it a potential candidate for treating a wide range of diseases, such as autoimmune disorders, sepsis, and inflammatory bowel disease. By modulating the immune response and reducing inflammation, C1 Esterase Inhibitor can help manage the symptoms and progression of these conditions.
Used in Drug Development:
C1 Esterase Inhibitor serves as a valuable target for drug development in the pharmaceutical industry. Researchers are actively investigating the potential of C1 INH as a therapeutic agent for various diseases, including cancer, cardiovascular diseases, and neurodegenerative disorders. By developing drugs that modulate the activity of C1 Esterase Inhibitor or its target enzymes, it may be possible to develop novel treatments for these conditions.
Used in Diagnostics:
C1 Esterase Inhibitor is used as a biomarker in the diagnosis of certain diseases, particularly hereditary angioedema. Measuring the levels of C1 INH in the blood can help healthcare professionals determine the presence of the condition and monitor the effectiveness of treatment. Additionally, C1 Esterase Inhibitor levels may also be used to assess the risk of other inflammatory and autoimmune disorders.
Biochem/physiol Actions
Esterase inhibitor C1 is a multifunctional regulator of all major kinin-generating protein cascade systems. It has been a therapeutic tool in the treatment of hereditary angioedema and complement-mediated inflammatory tissue damage such as capillary leak syndrome, septic shock, multiple organ failure, and hyperacute graft rejection.
Check Digit Verification of cas no
The CAS Registry Mumber 80295-38-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,2,9 and 5 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 80295-38:
(7*8)+(6*0)+(5*2)+(4*9)+(3*5)+(2*3)+(1*8)=131
131 % 10 = 1
So 80295-38-1 is a valid CAS Registry Number.