C4, HUMAN, also known as Complement Component 4, is a protein found in human serum that plays a crucial role in the immune system. It is involved in the activation of the complement system, which is a part of the innate immune response. C4, HUMAN is composed of two chains, α and β, linked by disulfide bonds and has a molecular weight of approximately 190 kDa. It is synthesized primarily in the liver and circulates in the blood as a precursor to its active form. C4, HUMAN is involved in the regulation of immune responses and the clearance of pathogens and immune complexes.
Source:
C4, HUMAN is produced in the liver and circulates in human serum.
Production Methods:
C4, HUMAN is synthesized in the liver and secreted into the bloodstream, where it circulates as an inactive precursor. It is activated by the cleavage of the α chain by the enzyme C1s, which is part of the classical pathway of the complement system.
Source:
C4, HUMAN is produced in the liver and circulates in human serum.
Production Methods:
C4, HUMAN is synthesized in the liver and secreted into the bloodstream, where it circulates as an inactive precursor. It is activated by the cleavage of the α chain by the enzyme C1s, which is part of the classical pathway of the complement system.
80295-48-3
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Basic information
- Product Name: C4, HUMAN
- Synonyms: C4, HUMAN;COMPLEMENT C4;COMPLEMENT C4, HUMAN;COMPLEMENT C4 FROM HUMAN SERUM
- CAS NO:80295-48-3
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: Complement Factor ProteinsProteins and Derivatives;Complement Proteins;ComplementCell Signaling Enzymes;Plasma Protein Composition;Plasma&Blood Proteins;Plasma, Blood, and Related Proteins and Reagents
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −70°C
- Solubility: N/A
- CAS DataBase Reference: C4, HUMAN(CAS DataBase Reference)
- NIST Chemistry Reference: C4, HUMAN(80295-48-3)
- EPA Substance Registry System: C4, HUMAN(80295-48-3)
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Safety Data
- Hazard Codes: B
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 2
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 80295-48-3(Hazardous Substances Data)
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80295-48-3 Usage
Uses
Used in Immunology Research:C4, HUMAN is used as a research tool in the study of the complement system and its role in immune responses. It is employed in various assays to investigate the activation and regulation of the complement system, as well as its interactions with other components of the immune system.
Used in Diagnostic Applications:
C4, HUMAN is used in diagnostic assays to measure the levels of C4 in serum samples. Abnormal levels of C4 can be indicative of certain immune disorders or infections, and its measurement can aid in the diagnosis and monitoring of these conditions.
Used in Mannose Binding Lectin (MBL) Complex Assay:
C4, HUMAN is used as a component of the MBL complex assay of serum samples. This assay is used to evaluate the function of the MBL pathway, which is an important part of the innate immune response.
Used in MBL-Associated Serine Proteases Based C4 Activation Assay:
C4, HUMAN is used as a substrate in the MBL-associated serine proteases based C4 activation assay of plasma samples. This assay is used to study the activation of C4 by MBL-associated serine proteases, which is a key step in the lectin pathway of the complement system.
Biochem/physiol Actions
Variation in the copy number of the complement C4 gene alters the complement c4A and c4B levels in age-related macular degeneration (AMD) and increases risk of developing schizophrenia.Check Digit Verification of cas no
The CAS Registry Mumber 80295-48-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,2,9 and 5 respectively; the second part has 2 digits, 4 and 8 respectively.Calculate Digit Verification of CAS Registry Number 80295-48:
(7*8)+(6*0)+(5*2)+(4*9)+(3*5)+(2*4)+(1*8)=133
133 % 10 = 3
So 80295-48-3 is a valid CAS Registry Number.
80295-48-3Upstream product
80295-48-3Downstream Products
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C4, HUMAN
