C5, HUMAN, also known as complement component 5, is a crucial protein in the terminal sequence of the complement pathway, an essential part of the immune system. It plays a significant role in the body's defense against pathogens and contributes to inflammation and chemotaxis. C5 is cleaved into C5a and C5b fragments, which are responsible for initiating the formation of the membrane attack complex (MAC) and modulating immune responses.
Source:
C5, HUMAN is a naturally occurring protein found in humans as part of the immune system.
Production Methods:
The production of C5, HUMAN typically involves recombinant DNA technology, where the gene encoding the protein is inserted into a host cell, such as bacteria or yeast, to produce the protein in large quantities for research and therapeutic purposes.
Source:
C5, HUMAN is a naturally occurring protein found in humans as part of the immune system.
Production Methods:
The production of C5, HUMAN typically involves recombinant DNA technology, where the gene encoding the protein is inserted into a host cell, such as bacteria or yeast, to produce the protein in large quantities for research and therapeutic purposes.
80295-53-0
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Basic information
- Product Name: C5, HUMAN
- Synonyms: C5, HUMAN;COMPLEMENT C5, HUMAN;COMPLEMENT C5;COMPLEMENT C5 FROM HUMAN SERUM
- CAS NO:80295-53-0
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: Complement Factor ProteinsProteins and Derivatives;Plasma Protein Composition;Complement Proteins;ComplementCell Signaling Enzymes;Plasma&Blood Proteins;Plasma, Blood, and Related Proteins and Reagents
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −70°C
- Solubility: N/A
- CAS DataBase Reference: C5, HUMAN(CAS DataBase Reference)
- NIST Chemistry Reference: C5, HUMAN(80295-53-0)
- EPA Substance Registry System: C5, HUMAN(80295-53-0)
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Safety Data
- Hazard Codes: B
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 80295-53-0(Hazardous Substances Data)
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80295-53-0 Usage
Uses
Used in Complement Pathway Regulation:C5, HUMAN is used as a key component in the regulation of the complement pathway, which is vital for the body's defense against infections and maintaining immune homeostasis. It helps in the activation of the immune response and the clearance of pathogens.
Used in Paroxysmal Nocturnal Hemoglobinuria (PNH) Treatment:
C5, HUMAN is used as a therapeutic target for the treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH) patients. Drugs that inhibit complement C5 have been employed to reduce thrombotic complications by decreasing intravascular hemolysis, thus improving the overall health and quality of life for PNH patients.
Used in Drug Development:
C5, HUMAN serves as a target for the development of new drugs and therapies aimed at modulating the immune response and treating various immune-related disorders. Inhibitors of C5 can potentially be used to treat other conditions where the complement pathway is dysregulated, such as autoimmune diseases and inflammatory conditions.
Biochem/physiol Actions
Complement component C5 is processed by convertase enzymes in a cascade modulated in a unique way. The multi-subunit catalytic complex initially shows little activity against C5, but instead cleaves C3. A C3 cleavage product C3b covalently attaches to the complex and shifts its specificity to C5 by a factor of 1000.Check Digit Verification of cas no
The CAS Registry Mumber 80295-53-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,2,9 and 5 respectively; the second part has 2 digits, 5 and 3 respectively.Calculate Digit Verification of CAS Registry Number 80295-53:
(7*8)+(6*0)+(5*2)+(4*9)+(3*5)+(2*5)+(1*3)=130
130 % 10 = 0
So 80295-53-0 is a valid CAS Registry Number.
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C5, HUMAN
