Factor H, Human, also known as Complement factor H, is a plasma regulator of the complement protein C3b in the alternative pathway of the complement system. It plays a crucial role in regulating the immune response and preventing damage to host cells. Its binding is important for the pathogenesis of group A streptococcus (GAS), and inhibition of this binding may be an effective management of GAS infections.
80295-65-4
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Basic information
- Product Name: FACTOR H, HUMAN
- Synonyms: BETA1H GLOBULIN;BETA1H GLOBULIN, HUMAN;COMPLEMENT FACTOR H;FACTOR H, HUMAN;complement factor H from human plasma
- CAS NO:80295-65-4
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: Complement Factor ProteinsProteins and Derivatives;Complement Proteins;ComplementCell Signaling Enzymes;Plasma Protein CompositionApplication Index;Plasma&Blood Proteins;Plasma, Blood, and Related Proteins and Reagents;Serum Proteins;Serum Proteins and Related Enzymes
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −70°C
- Solubility: N/A
- CAS DataBase Reference: FACTOR H, HUMAN(CAS DataBase Reference)
- NIST Chemistry Reference: FACTOR H, HUMAN(80295-65-4)
- EPA Substance Registry System: FACTOR H, HUMAN(80295-65-4)
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Safety Data
- Hazard Codes: B
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 80295-65-4(Hazardous Substances Data)
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80295-65-4 Usage
Uses
Used in Medical Industry:Factor H, Human is used as a therapeutic agent for the management of group A streptococcus (GAS) infections. Its role in regulating the immune response and preventing damage to host cells makes it a promising candidate for the development of new treatments for GAS infections.
Used in Research:
Factor H, Human is used as a research tool for studying the complement system and its role in the pathogenesis of various diseases. Understanding the mechanisms of Factor H binding and its regulation of the immune response can provide valuable insights into the development of new therapeutic strategies for a range of conditions.
Used in Drug Development:
Factor H, Human is used in the development of new drugs targeting the complement system. Inhibition of Factor H binding has been shown to be an effective strategy for managing GAS infections, and further research into its role in other diseases may lead to the development of new treatments for a variety of conditions.
Biochem/physiol Actions
Complement factor H plays an essential role in the homeostasis of the complement system and in preventing collateral damage to bystander cells and tissues by complement activation.Check Digit Verification of cas no
The CAS Registry Mumber 80295-65-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,2,9 and 5 respectively; the second part has 2 digits, 6 and 5 respectively.Calculate Digit Verification of CAS Registry Number 80295-65:
(7*8)+(6*0)+(5*2)+(4*9)+(3*5)+(2*6)+(1*5)=134
134 % 10 = 4
So 80295-65-4 is a valid CAS Registry Number.
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FACTOR H, HUMAN
