80306-38-3 Usage
Uses
Used in Biological Research:
7-Chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine is used as a CMA booster in the biological study of chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Its ability to activate CMA and increase LAMP-2A expression makes it a valuable tool for understanding the role of autophagy in various cellular processes and diseases.
Used in Parkinson's Disease Research:
In the field of neurodegenerative disease research, 7-Chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine is used to study its potential as a disease-modifying strategy for Parkinson's disease. It has been shown to stimulate CMA and attenuate the accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons, suggesting that CMA activation may help in the development of therapeutic approaches for Parkinson's disease.
Used in Cancer Research:
7-Chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine is also used in cancer research to investigate its effects on chaperone-mediated autophagy in cancer cells. A targetome analysis of AR7-induced CMA in cancer cells has been performed, providing insights into the molecular mechanisms underlying its potential anticancer properties. This research could contribute to the development of novel therapeutic strategies targeting autophagy pathways in cancer treatment.
References
Anguiano et al. (2013), Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives; Nat. Chem. Biol. 9 374
Ho et al. (2020), Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA); Autophagy 16 347
Bonam et al. (2021), Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease; Cells 10 3547
Hao et al. (2019), Targetome analysis of chaperone-mediated autophagy in cancer cells; Autophagy 15 1558
Check Digit Verification of cas no
The CAS Registry Mumber 80306-38-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,3,0 and 6 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 80306-38:
(7*8)+(6*0)+(5*3)+(4*0)+(3*6)+(2*3)+(1*8)=103
103 % 10 = 3
So 80306-38-3 is a valid CAS Registry Number.
80306-38-3Relevant academic research and scientific papers
RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS AND USES THEREOF
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Paragraph 0081; 0082; 0122, (2015/06/24)
Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RARα) in
Design, synthesis and biological evaluation of 2H-benzo[b][1,4] oxazine derivatives as hypoxia targeted compounds for cancer therapeutics
Das, Bhaskar C.,Madhukumar, Ankanahlli V.,Anguiano, Jaime,Mani, Sridhar
supporting information; experimental part, p. 4204 - 4206 (2010/04/05)
A small library of 2H-benzo[b][1,4] oxazine derivative was synthesized and their biological activity was tested on HepG2 cells under normoxic and hypoxic conditions. From preliminary screening, we found compound 10 and 11 specifically inhibit hypoxic canc
