80306-60-1

Upstream product

• 614-78-8 o-tolylthiourea 
• 79-22-1 methyl chloroformate 
• 74-88-4 methyl iodide 
• 95-53-4 o-toluidine 
• 4949-88-6 N-benzoyl-N'-(2-methylphenyl)thiourea 

Downstream Products

• 80306-55-4 3-('-Methylphenyl)-2-methylmercapto-4-(3H)pyrimidone 
• 82636-27-9 3-(2'-Methylphenyl)-2-methylmercapto-4-(3H)pyrimidone-5-carboxylic acid 
• 89069-47-6 3-(2-methylphenyl)-2-methylthio-6-phenyl-4(3H)-pyrimidinones 
• 89069-38-5 6-methyl-3-(2-methylphenyl)-2-methylthio-4(3H)-pyrimidinone 
• 82635-90-3 Diethyl N-<(2-methylphenyl)-2-methylmercapto>-amidinomethylenemalonate 
• 82636-16-6 Ethyl 3-(2'-methylphenyl)-2-methylmercapto-4-(3H)pyrimidone-5-carboxylate 

Relevant academic research and scientific papers

Synthesis and Biological Activity of Some New 1-Aryl-2-S-methyl-5-(2-pyridyl/2-furfuryl)isodithiobiurets

A number of 1-aryl-2-S-methyl-5-(2-pyridyl/2-furfuryl)isodithiobiurets (II and III) have been synthesized by the condensation of various N-aryl-S-methylisothioureas (V) with 2-pyridyl- and 2-furfurylisothiocyanates and tested for anthelmintic, antiamoebic, antitrichomonal, antileishmanial and antimicrobial activities.

Synthesis & Pharmacological Evaluation of Ethyl 3-Substituted-phenyl-2-methylmercapto/ phenyl/ methyl-4(3H)-pyrimidone-5-carboxylates

A number of ethyl 3-substituted-phenyl-2-methylmercapto/ phenyl/ methyl-4(3H)-pyrimidone-5-carboxylates (V) have been prepared by the reaction of amidines (III) with diethyl ethoxymethylenemalonate.In order to confirm the structure (V), ethyl 3-(2'-methylphenyl)-2-methylmercapto-4(3H)pyrimidone-5-carboxylate (103) has been transformed into the earlier synthesised 3-(2'-methylphenyl)-2-methylmercapto-4(3H)-pyrimidone (115) by decarboxylation of 3-(2'-methylphenyl)-2-methylmercapto-4(3H)-pyrimidone-5-carboxylic acid (114), obtained by the alkaline hydrolysis of 103.Someof these compounds have shown antiinflammatory, diuretic and antipassive cutaneous anaphylaxis activities.