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Usage

Uses

Used in Pharmaceutical Industry:
2-(chloromethyl)-1-methoxy-4-(2-methoxyethyl)benzene is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medical treatments.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(chloromethyl)-1-methoxy-4-(2-methoxyethyl)benzene is utilized as a precursor for the production of certain agrochemicals. Its role in this industry is crucial for the creation of effective products that support agricultural practices.
Used in Organic Synthesis:
2-(chloromethyl)-1-methoxy-4-(2-methoxyethyl)benzene is used as a valuable intermediate in organic synthesis. Its properties make it a versatile compound that can be transformed into a wide range of industrial chemicals, showcasing its importance in the chemical industry.
Regulatory Considerations:
Due to its identification as a potential genotoxic impurity, 2-(chloromethyl)-1-methoxy-4-(2-methoxyethyl)benzene is subject to strict regulations in the pharmaceutical industry. These regulations are in place to ensure its safe use and to mitigate any potential risks associated with its presence in pharmaceutical products.

Upstream product

• 50-00-0 formaldehyd 
• 80314-58-5 1-methoxy-4-(2-methoxyethyl)benzene 
• 702-23-8 2-(4-Methoxyphenyl)ethanol 
• 104-01-8 4-Methoxyphenylacetic acid 

Downstream Products

• 80318-67-8 dimethyl 3,6,8-trihydroxy-7-<2'-methoxy-5'-(2''-methoxyethyl)phenyl>-9,10-dioxo-9,10-dihydroanthracene-1,2-dicarboxylate 
• 80314-57-4 1-Methoxy-4-(2-methoxy-ethyl)-2-{1-[1-methoxy-1-trimethylsilanyloxy-meth-(Z)-ylidene]-2-trimethylsilanyloxy-allyl}-benzene 
• 80314-62-1 (E)-2-[2-Methoxy-5-(2-methoxy-ethyl)-phenyl]-3-trimethylsilanyloxy-but-2-enoic acid methyl ester 
• 80314-60-9 2-[2-Methoxy-5-(2-methoxy-ethyl)-phenyl]-3-oxo-butyronitrile 
• 80314-59-6 <2'-methoxy-5'-(2''-methoxyethyl)phenyl>acetonitrile 

Relevant academic research and scientific papers

RENIN INHIBITORS

Renin inhibitors, which are spirocyclic piperidine amides, of structural formula (I) and pharmaceutical compositions thereof useful in the treatment of cardiovascular diseases and renal insufficiency, wherein n, for each instance in which it occurs, is independently 0, 1, or 2; R1 is hydrogen, C1-6 -alkyl or C3-6 -cycloalkyl, wherein said C1-6 -alkyl or C3-6 -cycloalkyl group can be independently substituted with 1-3 halogens; A is (i) a five- or six-membered saturated or unsaturated heterocyclic or carbocyclic monocyclic ring or (ii) a five- or six-membered saturated or unsaturated heterocyclic or carbocyclic ring which is fused to another five- or six-membered saturated or unsaturated heterocyclic or carbocyclic ring, V is a bond or -(C=O)-, -CH(OH)-, -CH2- or =CH-; U is a bond or -CH2-, or for the case when V is =CH-, U is -CH=; X is =CH-, =CF-, =C(OR3)-, or -C=O-; and Y is =CH-, =CF-, =N-, or for the case when X is -C=O-, Y is -N(R3)-.

Chemistry of the Coccoidea. X Synthesis of the Xantholaccaic Acid B System and of Related Compounds

Xantholaccaic acid B dimethyl ester pentamethyl ether (6) and some related anthraquinones have been synthesized by regiospecific Diels-Alder addition of the highly functionalized dienes (12) and (27) successively to 2,6-dichloro-1,4-benzoquinone.This is the first synthesis of the β-arylanthraquinone skeleton characteristic of the water-soluble dyestuffs from lac insects.

SYNTHESIS OF THE XANTHOLACCAIC ACID B SYSTEM

The xantholaccaic acid B system has been synthesized for the first time by successive regiospecific Diels-Alder reactions.