80322-07-2

Basic information

• Product Name: 1,1-Diethoxy-2-methyl-octan-3-ol
• Synonyms: 1,1-Diethoxy-2-methyl-octan-3-ol
• CAS NO: 80322-07-2
• Molecular Weight: 232.364
• Mol File: 80322-07-2.mol

Chemical Properties

• CAS DataBase Reference: 1,1-Diethoxy-2-methyl-octan-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-Diethoxy-2-methyl-octan-3-ol(80322-07-2)
• EPA Substance Registry System: 1,1-Diethoxy-2-methyl-octan-3-ol(80322-07-2)

Safety Data

• Hazardous Substances Data: 80322-07-2(Hazardous Substances Data)

Upstream product

• 54827-24-6 2-diethoxymethyl-oct-1-en-3-ol 
• 17592-40-4 2-bromo-3,3-diethoxypropene 
• 66-25-1 hexanal 

Downstream Products

• 49576-57-0 (2E)-2-methyloct-2-enal 

Relevant articles and documents

Aldolisation dirigee avec l'acroleine. Methode de synthese stereoselective de doubles liaisons trisubstituees fonctionnalisees. Application a la synthese du (+/-)-Z-chloronuciferal et du (+/-)-E-nuciferol

To direct the aldolisation reaction in such a way that an aldehyde reacts upon the electrophilic carbonyl group of a ketone or of another aldehyde, it is necessary to mask the aldehyde and to transform it into a nucleophile.The present article presents an approach to this problem concerning unsaturated aldehydes and describes the condensation between the α-carbanion of acrolein and several carbonyl compounds. Aldol condensation at -70 degC, between 1,1-diethoxy-2-lithio-2-propene and several aldehydes leads to β-hydroxy-α-methylene acetals.These secondary allylic alcohols are stereoselectively transformed into trisubstituted functionalised olefinic compounds (Z-α-chlormethyl-α,β-unsaturated aldehydes and E-α-methyl-α,β-unsaturated primary alcohols). This method is illustrated by the syntheses of (+/-)-Z-chloronuciferal and (+/-)-E-nuciferol.