80326-37-0

Basic information

• Product Name: 3,5-Cyclooctadien-1-one
• CAS NO: 80326-37-0
• Molecular Formula: C8H10O
• Mol File: 80326-37-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,5-Cyclooctadien-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Cyclooctadien-1-one(80326-37-0)
• EPA Substance Registry System: 3,5-Cyclooctadien-1-one(80326-37-0)

Safety Data

• Hazardous Substances Data: 80326-37-0(Hazardous Substances Data)

Upstream product

• 3806-59-5 1,3-cyclooctadiene 
• 108-24-7 acetic anhydride 

Downstream Products

• 80339-91-9 1,3-Cyclooctadien-6-in 
• 80326-39-2 5,6-Dihydro-1,2,3,4-tetraphenylbenzocycloocten 

Relevant articles and documents

Synthesis of cycloocta-3,5-dien-1-ol and cycloocta-3,5-dien-1-one: SeO2/O2 oxidation of dienes

A useful synthesis of cycloocta-3,5-dien-1-ol was developed starting from cycloocta-1,3-diene. Oxidation of the diene with selenium oxide in refluxing acetic anhydride affords the homoallylic and allylic acetates in a 19:1 ratio and a 36% overall yield when O2 is bubbled through the reaction mixture. Subsequent reduction with LAH affords the homoallylic alcohol (95%), which can be readily oxidized via TPAP/N-MMO (73%) to the corresponding non-conjugated dienone. This route represents the most efficient method for the preparation of cycloocta-3,5-dien-1-ol and cycloocta-3,5-dien-1-one reported to date, and may provide a general approach to the synthesis of homoallylic alcohols and non-conjugated enones.