80335-46-2

Basic information

• Product Name: 4-[(diethylamino)methyl]benzoyl chloride
• CAS NO: 80335-46-2
• Molecular Formula: C₁₂H₁₆ClNO
• Molecular Weight: 225.7145
• Mol File: 80335-46-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 290.8°C at 760 mmHg
• Flash Point: 129.7°C
• Density: 1.098g/cm³
• Vapor Pressure: 0.00203mmHg at 25°C
• Refractive Index: 1.532
• CAS DataBase Reference: 4-[(diethylamino)methyl]benzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(diethylamino)methyl]benzoyl chloride(80335-46-2)
• EPA Substance Registry System: 4-[(diethylamino)methyl]benzoyl chloride(80335-46-2)

Safety Data

• Hazardous Substances Data: 80335-46-2(Hazardous Substances Data)

Upstream product

• 68453-55-4 methyl 4-((diethylamino)methyl)benzoate 
• 62642-59-5 4-diethylaminomethyl-benzoic acid 
• 1571-08-0 methyl 4-formylbenzoate 

Relevant articles and documents

Combination of 4-anilinoquinazoline, arylurea and tertiary amine moiety to discover novel anticancer agents

In present study, 4-anilinoquinazolines scaffold, arylurea and tertiary amine moiety were combined to design, synthesize gefitinib analogs and discover novel anticancer agents. A series of 4-anilinoquinazoline derivatives (1, 2, 3 and 4) bearing arylurea and tertiary amine moiety at its 6-position were synthesized. Their antiproliferative activities in vitro were evaluated via MTT assay against A431 cell and A549 cell. The SAR of the title compounds was discussed. The compounds 2d, 2i and 2j with potent antiproliferative activities were evaluated their inhibitory activity against EGFR-TK. Compound 2j displayed potent inhibitory activity against EGFR-TK. In addition, compound 2j, at 50 mg/kg, can completely inhibit cancer growth in established nude mouse A549 xenograft model in vivo. These results suggest that the 4-anilinoquinazoline derivatives bearing diarylurea and tertiary amino moiety at its 6-position can serve as anticancer agents and EGFR inhibitors.