80337-72-0Relevant academic research and scientific papers
An efficient synthesis of 2,4′-bi-1,3-oxa(thia)zoles as scaffolds for bioactive products
Pena,Scarone,Manta,Serra
, p. 703 - 709 (2012/02/01)
A rapid and efficient methodology to prepare 2,4′-bi-1,3-azoles as scaffolds for biologically active marine natural products is described. Hantzsch reaction and oxidative cyclodehydration of β-hydroxy amides or thioamides were used to construct the azole rings. The obtained biheterocycles displayed no cytotoxicity on HCT-15 cell line.
