80357-30-8Relevant articles and documents
An efficient method for the construction of polysubstituted 4-pyridones via self-condensation of β-keto amides mediated by P2O5 and catalyzed by zinc bromide
Tan, Liquan,Zhou, Peng,Chen, Cui,Liu, Weibing
supporting information, p. 2681 - 2687 (2014/01/06)
A self-condensation cyclization reaction mediated by phosphorus pentoxide (P2O5) and catalyzed by zinc bromide (ZnBr2) is presented for the synthesis of polysubstituted 4-pyridones and 2-pyridones from β-keto amides. A var
Approach to polysubstituted 4-pyridones from N-Aryl acetoacetamides via a N to C 1,3-acyl migration mediated by sodium persulfate
Zhang, Zhiguo,Fang, Shiliang,Liu, Qingfeng,Zhang, Guisheng
, p. 7665 - 7670 (2012/10/30)
Mediated by sodium persulfate (Na2S2O8), a series of polysubstituted 4-pyridones were synthesized via self-condensation of N-aryl acetoacetamides, during which a novel N to C 1,3-acyl migration should be involved. The stru
Preparation and Antiinflammatory Activity of 2- and 4-Pyridones
Pierce, James Benjamin,Ariyan, Zaven S.,Ovenden, Gaye Stuart
, p. 131 - 136 (2007/10/02)
Several N-alkyl- and N-arylacetoamides have been self-condensed to form pyridones.N-Alkylacetoacetamides give 2-pyridones, while N-arylacetoamides give 4-pyridones.In an attempt to develop nonacidic, nonsteroidal antiinflammatory agents, the pyridones were tested in a carrageenan-induced pedal edema assay in rats.While the 2-pyridones were not active, 9 of 17 4-pyridones tested were active, and one compound (4g) had antiinflammatory efficacy in a dose-response assay (ED50 values).Most compounds were considered nontoxic by determination of approximate LD50 values in mice by a standard multidimensional observational assay.
