80357-41-1

Basic information

• Product Name: 1-(2,6-Dimethyl-phenyl)-2,6-dimethyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid (2,6-dimethyl-phenyl)-amide
• Synonyms: 1-(2,6-Dimethyl-phenyl)-2,6-dimethyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid (2,6-dimethyl-phenyl)-amide
• CAS NO: 80357-41-1
• Molecular Weight: 374.483
• Mol File: 80357-41-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2,6-Dimethyl-phenyl)-2,6-dimethyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid (2,6-dimethyl-phenyl)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,6-Dimethyl-phenyl)-2,6-dimethyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid (2,6-dimethyl-phenyl)-amide(80357-41-1)
• EPA Substance Registry System: 1-(2,6-Dimethyl-phenyl)-2,6-dimethyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid (2,6-dimethyl-phenyl)-amide(80357-41-1)

Safety Data

• Hazardous Substances Data: 80357-41-1(Hazardous Substances Data)

Upstream product

• 52793-02-9 N-(2,6-dimethylphenyl)-3-oxobutanamide 

Relevant articles and documents

Preparation and Antiinflammatory Activity of 2- and 4-Pyridones

Several N-alkyl- and N-arylacetoamides have been self-condensed to form pyridones.N-Alkylacetoacetamides give 2-pyridones, while N-arylacetoamides give 4-pyridones.In an attempt to develop nonacidic, nonsteroidal antiinflammatory agents, the pyridones were tested in a carrageenan-induced pedal edema assay in rats.While the 2-pyridones were not active, 9 of 17 4-pyridones tested were active, and one compound (4g) had antiinflammatory efficacy in a dose-response assay (ED50 values).Most compounds were considered nontoxic by determination of approximate LD50 values in mice by a standard multidimensional observational assay.