80357-48-8

Basic information

• Product Name: N-(2,3-DIMETHYLPHENYL)-3-OXOBUTANAMIDE
• Synonyms: N-(2,3-DIMETHYLPHENYL)-3-OXOBUTANAMIDE;2',3'-ACETOACETOXYLIDIDE
• CAS NO: 80357-48-8
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.25
• Mol File: 80357-48-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 367.3°Cat760mmHg
• Flash Point: 149.6°C
• Appearance: /
• Density: 1.108g/cm³
• CAS DataBase Reference: N-(2,3-DIMETHYLPHENYL)-3-OXOBUTANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,3-DIMETHYLPHENYL)-3-OXOBUTANAMIDE(80357-48-8)
• EPA Substance Registry System: N-(2,3-DIMETHYLPHENYL)-3-OXOBUTANAMIDE(80357-48-8)

Safety Data

• Hazardous Substances Data: 80357-48-8(Hazardous Substances Data)

Upstream product

• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 87-59-2 2,3-Dimethylaniline 
• 1352630-24-0 3-(2,3-dimethylphenylamino)-2-[(2,3-dimethylphenylimino)methyl]acrylonitrile 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 1088497-31-7 C₂₆H₂₅N₃O₃ 
• 944938-86-7 C₂₃H₂₂N₄O₃ 
• 1095943-83-1 C₁₄H₁₉NO₂ 

Relevant articles and documents

Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators

Free fatty acid receptor 3 (FFA3, previously GPR41) is activated by short-chain fatty acids, mediates health effects of the gut microbiota, and is a therapeutic target for metabolic and inflammatory diseases. The shortage of well-characterized tool compounds has however impeded progress. Herein, we report structure-activity relationship of an allosteric modulator series and characterization of physicochemical and pharmacokinetic properties of selected compounds, including previous and new tools. Two representatives, 57 (TUG-1907) and 63 (TUG-2015), showed improved solubility and preserved potency. Of these, 57, with EC50 = 145 nM and a solubility of 33 μM, showed high clearance in vivo but is a preferred tool in vitro. In contrast, 63, with EC50 = 162 nM and a solubility of 9 μM, showed lower clearance and seems better suited for in vivo studies. Using 57, we demonstrate for the first time that FFA3 activation leads to calcium mobilization in murine dorsal root ganglia.

Inter-and intra-molecular cyclisation reactions of azoacetates derived from aryl hydrazones of ethyl acetoacetate and acetoacetanilides

The base induced cyclisations of azoacetates to azetidinones were investigated. In addition to the isolation of the desired products, it was found that 2-iminopyrrolidine-5-one derivatives as well as N-acyl hydrazides could be isolated when metal cyanides were employed as base. These entities were further modified to form pyrrolidine-2,5-diones and diazetidinones respectively. The Japan Institute of Heterocyclic Chemistry.