80357-50-2Relevant academic research and scientific papers
Oxidative nuclear bromination of substituted 4-pyridones using pyridinium bromochromate
Zhang, Zhiguo,Qian, Jingjing,Tian, Qing,Liu, Tongxin,Liu, Qingfeng,Zhang, Guisheng
supporting information, p. 674 - 681 (2014/01/17)
An alternative convenient approach for the bromination of various poly-substituted 4-pyridones has been developed via an oxidative nuclear bromination in the presence of sole pyridinium bromochromate (PBC). The PBC performs the dual role of oxidant and so
Preparation and Antiinflammatory Activity of 2- and 4-Pyridones
Pierce, James Benjamin,Ariyan, Zaven S.,Ovenden, Gaye Stuart
, p. 131 - 136 (2007/10/02)
Several N-alkyl- and N-arylacetoamides have been self-condensed to form pyridones.N-Alkylacetoacetamides give 2-pyridones, while N-arylacetoamides give 4-pyridones.In an attempt to develop nonacidic, nonsteroidal antiinflammatory agents, the pyridones were tested in a carrageenan-induced pedal edema assay in rats.While the 2-pyridones were not active, 9 of 17 4-pyridones tested were active, and one compound (4g) had antiinflammatory efficacy in a dose-response assay (ED50 values).Most compounds were considered nontoxic by determination of approximate LD50 values in mice by a standard multidimensional observational assay.
