80360-57-2

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 47, p. 893, 1982 DOI: 10.1021/jo00344a030

Upstream product

• 106-95-6 allyl bromide 
• 1759-53-1 cyclopropanecarboxylic acid 
• 106434-82-6 1-(2-Propenyl)cyclopropancarbonsaeure-methylester 
• 108546-98-1 1-allyl-cyclopropanecarboxylic acid tert-butyl ester 
• 80375-26-4 C₄H₄LiO₂^(1-)*Li⁽¹⁺⁾ 

Downstream Products

• 20225-24-5 2-ethylvaleric acid 
• 104131-82-0 1-propylcyclopropane-1-carboxylic acid 
• 106455-75-8 C₉H₁₃⁽²⁾H₂NO₂ 
• 106434-82-6 1-(2-Propenyl)cyclopropancarbonsaeure-methylester 
• 816-16-0 2-Ethylpentansaeure-methylester 
• 104131-81-9 1-Propyl-cyclopropanecarboxylic acid methyl ester 

Relevant academic research and scientific papers

mCPBA-mediated dioxygenation of unactivated alkenes for the synthesis of 5-imino-2-tetrahydrofuranyl methanol derivatives

A mCPBA-mediated, metal-free, intramolecular dioxygenation reaction of unactivated alkenes is reported. In the presence of m-chlorobenzoic peracid, different unsaturated amide substrates could be cyclized via epoxide intermediates, producing the corresponding 5-imino-2-tetrahydrofuranyl methanol products in up to 94% yield at room temperature.

PRODRUGS OF CGRP ANTAGONISTS

Disclosed are prodrugs of CGRP antagonists, methods of treating CGRP related disorders, e.g., migraine, by administering to a patient in need thereof the prodrugs, pharmaceutical compositions comprising prodrugs and kits including the pharmaceutical compositions and instructions for use.

Copper(II)-Catalyzed Alkene Aminosulfonylation with Sodium Sulfinates for the Synthesis of Sulfonylated Pyrrolidones

A copper-catalyzed direct aminosulfonylation of unactivated alkenes with sodium sulfinates for the efficient synthesis of sulfonylated pyrrolidones is described. This reaction features good functional group tolerance and wide substrate scope, providing an efficient and straightforward protocol to access this kind of pyrrolidones. Moreover, preliminary mechanistic investigations disclosed that a free-radical pathway might be invovled in the process.

Ortho-substituted benzyl esters of cyclopropanecarboxylic acids

Ortho-substituted benzyl esters of cyclopropanecarboxylic acids I STR1 where X is N or CH and A is one of the following cyclopropane radicals: STR2 where R1 is CN, C2 -C8 -alkyl, CF3, C3 -C8 -alkenyl, (C1 -C4 -alkoxycarbonyl, unsubstituted or substituted phenyl-C1 -C6 -alkyl or phenyl-C3 -C6 -alkenyl, ethoxyphenyl, 2- or 3-bromophenyl, 2- or 4-trifluoromethylphenyl, 2,4- or 2,6-difluorophenyl, 2-fluoro-6-chlorophenyl, 2,4- or 2,6-dimethylphenyl, 2,3,6-trichlorophenyl or trimethylsilyl, R2 is H or halogen, R3 is unsubstituted or substituted phenyl, R4 is CH3 or halogen and Hal is halogen, with the proviso that X is CH when R1 is CF3 or trimethylsilyl, are suitable as fungicides and for controlling pests.